S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.

2024年12月25日 · S100B (S100 Calcium Binding Protein B) is a Protein Coding gene. Diseases associated with S100B include Syringoma and Granular Cell Tumor. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Interleukin-1 family signaling.

In this work, we review and compare S100B and GFAP's pathobiological characteristics and discuss the evidence for their use in different neurological conditions (9 – 12) with a focus on mild traumatic brain injury (mTBI).

Serum S100beta levels may serve as a potentially useful early marker of postcraniotomy brain damage in patients undergoing elective meningioma resection. Increased plasma S100B level is found following acute spontaneous intracerebral hemorrhage, in association with a worse early and late evolution, and closely related to initial hematoma volume.

2025年2月8日 · Findings indicate the role of S100B in gliomagenesis and suggest the development of more potent S100B inhibitors for glioma therapy. levels of S100B differentially affect skeletal muscle repair upon acute injury and in the context of muscular dystrophy, and S100B might be regarded as a potential molecular target in Duchenne muscular dystrophy .

01S100蛋白家族结构S100蛋白于1965年由Moore首先在牛脑中发现，因其能溶解于中性100％硫酸铵中而得名。 S100蛋白是一个酸性的Ca2+结合蛋白家族，主要存在于脊椎动物中，相对分子质量小，10～12KDa。 目前至少已发现20个S100蛋白家族成员‚包含S100A1-A15、S100B、S100P等，具有组织特异性。 细胞内主要以同型二聚体形式存在，还有异型二聚体、三聚体及四聚 …

2004年9月17日 · The expression of astrocyte marker proteins (S100beta and GFAP) during infarction and glial scar formation after transient middle cerebral artery (MCA) occlusion was examined using double immunostaining. S100beta immunoreactivity markedly decreased in the core of the injured area when observed immed …

2003年6月1日 · Elevated S100beta levels may indicate the presence of radiologically detectable BBB leakage. Larger prospective studies may better determine the true specificity of S100beta as a marker for BBB function and as an early detection or follow-up marker of brain tumors.

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，成簇位于染色体 1q21；然而，该基因位于 21q22.3。 这种蛋白质可能在神经突延伸、黑色素瘤细胞增殖、刺激 Ca2+ 通量、抑制 PKC 介导的磷酸化、星形细胞增多和轴突增殖以及抑制微管组装中发挥作用。 该基因的染色体重排和表达改变与多种神经系统疾病 …

S100B is a Ca 2+ -binding protein mainly concentrated in astrocytes. Its levels in biological fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are recognized as a reliable biomarker of active neural distress.