Jun 29, 2022 · Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules that are ubiquitously expressed in the human body and play an important role in the immune system. S1P-S1PR signaling has been well characterized in immune trafficking and activation in both innate and adaptive immu …

Oct 18, 2019 · Sphingosine 1-phosphate (S1P), a product of membrane sphingolipid metabolism, is secreted and acts through G protein–coupled S1P receptors (S1PRs) in vertebrates. S1PR isoforms mediate complex cellular actions either alone or in combination in most organ systems.

The bioactive sphingolipid metabolite, sphingosine-1-phosphate (S1P), is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis. S1P is produced in ...

Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules that are ubiquitously expressed in the human body and play a fundamental role in the trafficking and activation in the immune system.

Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, including lymphocyte/hematopoietic cell trafficking.

Aug 23, 2019 · The S1P-S1P receptor signaling system plays important roles in lymphocyte trafficking and maintenance of vascular integrity, thus contributing to the regulation of complex inflammatory processes. S1P is enriched in blood and lymph while maintained low in intracellular or interstitial fluids, creating a steep S1P gradient that is utilized to ...

Oct 18, 2023 · S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such as cell growth, movement, programmed cell death,...

Sphingosine 1-phosphate (S1P) is a a variety of Sphingolipids (SFs) metabolites capable of performing various biological activities. S1P is commonly found in platelets, red blood cells, neutrophils, lymph fluid, and blood, as well as other cells and body fluids.

Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many...

在质膜上，鞘脂可以转化为鞘氨醇（Sph），再被鞘氨醇激酶（SPHK或SK）催化生成鞘氨醇1-磷酸（S1P）。 S1P也属于溶血磷脂，是重要的生物活性介质，参与多种信号转导途径，调节许多不同的细胞功能。 S1P与神经酰胺都被称作“生物活性鞘脂”，二者的功能在许多方面是互相拮抗的。 在神经系统中，神经酰胺和S1P参与神经元生存与死亡调控，参与AD、PD和衰老等生理病理 …