Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 …
2021年8月19日 · ApoM enriches S1P (sphingosine-1-phosphate) within HDL (high-density lipoproteins) and facilitates the activation of the S1P 1 (S1P receptor type 1) by S1P, thereby …
The apoM/S1P Complex-A Mediator in Kidney Biology and Disease?
2021年10月14日 · Accumulating evidence suggests that the apolipoprotein M/sphingosine-1-phosphate (apoM/S1P) axis is a likely drug target, but significant gaps in our knowledge …
Apolipoprotein M mediates sphingosine-1-phosphate efflux …
2017年11月8日 · Sphingosine-1-phosphate (S1P) is a bioactive lipid implicated in e.g. angiogenesis, lymphocyte trafficking, and endothelial barrier function. Erythrocytes are a main …
Binding Characteristics of Sphingosine-1-Phosphate to ApoM
2016年8月1日 · Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator carried by the HDL-associated apoM protein in blood, regulating many physiological processes by activating...
A Novel Perspective on the ApoM-S1P Axis, Highlighting the …
2017年7月27日 · ApoM is a typical lipocalin containing a hydrophobic binding pocket predominantly carrying Sphingosine-1-Phosphate (S1P). The small signaling molecule S1P is …
载脂蛋白M-1磷酸鞘氨醇与疾病关系的研究进展 - 中华检验医学杂志
载脂蛋白M(apolipoprotein M, apoM）是载脂蛋白家族中的一员，主要与高密度脂蛋白（high density lipoprotein, HDL）结合。自apoM被证明是1磷酸鞘氨醇（Sphingosine-1-phosphate, …
The apoM/S1P Complex—A Mediator in Kidney Biology and Disease?
2021年10月14日 · Importantly, apoM is a carrier of the bioactive lipid S1P. S1P acts by binding to five different receptors. Together, apoM/S1P plays a role in several biological mechanisms, …
Apolipoprotein M supports S1P production and conservation and …
2023年7月31日 · Three S1P carrier proteins have been reported, albumin, apolipoprotein M (ApoM) and apolipoprotein A4 (ApoA4). The carrier-bound S1P exerts its functions via specific …
Sphingosine 1-Phosphate and Atherosclerosis - PubMed
2018年1月1日 · S1P bound to albumin exerts both beneficial and harmful effects in the pathogenesis of atherosclerosis, while S1P bound to apoM strengthens anti-atherosclerotic …
Association of apolipoprotein M and sphingosine-1-phosphate
2022年11月5日 · ApoM deficiency in mice is associated with increased vascular permeability, brown adipose tissue (BAT) mass and activity, and protection against obesity. In the current …