Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive sphingolipid, which regulates the adhesion between the cells and the extracellular matrix and affects cell migration and differentiation. The goal of this study was to analyze the correlations among S100A4, S1P, and pulmonary function among COPD patients.

2022年3月20日 · Our findings suggest that S1P is a potential diagnostic biomarker in distinguishing COPD with CAP from AECOPD. Additionally, the diagnostic ability of S1P can be improved when used in combination with CRP.

S1P can be dephosphorylated back to sphingosine by two phosphatases (SGPP 1 and 2) or can be irreversibly cleaved by S1P lyase. S1P has a diverse range of functions, which is mediated in a receptor dependent, through G-protein coupled receptors (S1PR1–5) or receptor independent manner, through intracellular targets such as HDACs and TRAF2.

2015年10月20日 · Our results suggest a potential link between the S1P signalling system and defective macrophage phagocytic function in COPD and advise therapeutic targets. Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide.

2022年3月14日 · 一项研究表明，S1P紊乱与不同组织中的炎症反应和癌变有关。 动物实验表明，吸烟诱导的COPD小鼠肺S1P升高。 然而，在COPD患者中，S100A4、S1P和肺纤维化之间的关联尚不清楚。 S100A4是S100钙结合蛋白家族的成员，在慢性阻塞性肺疾病 (COPD)患者中增加。 鞘氨醇-1-磷酸 (S1P)是一种天然存在的生物活性鞘磷脂，调节细胞与细胞外基质的粘附，影响细胞的迁移和分化。 本研究的目的是分析慢性阻塞性肺疾病 (COPD)患者S100A4、S1P与肺功能 …

2022年2月22日 · Oxidative Medicine and Cellular Longevity杂志的一项研究评估了COPD患者S100A4、S1P与肺功能之间的关系。 研究纳入安徽COPD队列研究的139名患者，每名COPD患者都根据性别和年龄匹配一个对照组。

2022年2月3日 · Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive sphingolipid, which regulates the adhesion between the cells and the extracellular matrix and affects cell migration and differentiation. The goal of this study was to analyze the correlations among S100A4, S1P, and pulmonary function among COPD patients.

Background and purpose: A critical role for sphingosine kinase/sphingosine-1-phosphate (S1P) pathway in the control of airway function has been demonstrated in respiratory diseases. Here, we address S1P contribution in a mouse model of mild …

We found that macrophages of COPD individuals differentiated into M1 phenotype, and the expression of S1PR1 increased and HDAC1 decreased. S1PR1 also inhibits the expression of HDAC1, so S1PR1/HDAC1 signal regulates the polarization of macrophages.

2023年10月18日 · S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such as cell growth, movement, programmed...