GRK2-dependent S1PR1 desensitization is required for ... - PubMed
2011年9月30日 · Here, we show that heterotrimeric guanine nucleotide-binding protein-coupled receptor kinase-2 (GRK2) functions in down-regulation of S1P receptor-1 (S1PR1) on blood …
G-protein coupled receptor kinase-2 regulates the migration of
2025年2月24日 · GRK2 inhibits the egress of normal B cells from lymphoid tissues by inducing the downregulation of the S1P-receptor 1 (S1PR1). In this study we investigated the role of …
GRK2-Dependent S1PR1 Desensitization Is Required for
2011年9月30日 · Here, we show that heterotrimeric guanine nucleotide–binding protein–coupled receptor kinase-2 (GRK2) functions in down-regulation of S1P receptor-1 (S1PR1) on blood …
G-protein coupled receptor kinase-2 regulates the migration of
2025年2月24日 · GRK2 inhibits the egress of normal B cells from lymphoid tissues by inducing the downregulation of the S1P-receptor 1 (S1PR1). In this study we investigated the role of …
New roles of G protein-coupled receptor kinase 2 (GRK2) in cell ...
We have further shown that increased GRK2 protein levels promote enhanced ERK1/2 signalling downstream integrin receptor occupancy in a S1P receptor-dependent manner. Thus, GRK2 …
Regulation of Immune Cell Migration by Sphingosine-1-Phosphate
In this review, we summarize the roles of S1P signaling in regulating immune cell trafficking and discuss recent advances that have shed light on the underlying mechanism by which S1P …
G protein-coupled receptor kinase 2 positively regulates ... - PubMed
2008年4月23日 · GRK2 positively modulates the activity of the Rac/PAK/MEK/ERK pathway in response to adhesion and S1P by a mechanism involving the phosphorylation-dependent, …
G protein-coupled receptor kinase type 2 and β-arrestin2: Key …
2022年7月1日 · A buildup of excessive S1P-1R signaling occurs in combination with inadequate homeostatic chemokine receptor signaling when GRK2 is knocked out [113]. The latest study …
Constitutive activation of S1P receptors at the
2021年11月11日 · The Golgi cargo accumulation-induced S1PR internalization may be initiated by the receptor phosphorylation catalyzed by GRK2 at the PM because siRNA-induced …
The complex G protein‐coupled receptor kinase 2 (GRK2 ... - Wiley
2010年5月24日 · S1P-mediated Src-like activation first triggers GRK2 phosphorylation at tyrosine residues and promotes GRK2/GIT interaction; subsequent phosphorylation of GRK2 by MAPK …