When blocking PI3K signal, the effect of IGF-1 on promoting AEC migration was partially eliminated. IGF-1 induced AECs to produce S1P, which accelerated AEC migration through S1PR1.

2023年10月18日 · PI3K, Akt, and mTOR activation by S1P/S1PR1 have been demonstrated to control multiple cellular processes in the immune system, nervous system, and the proliferation of endothelial progenitor...

2013年8月1日 · S1P activated phosphatidylinositol 3-kinase (PI3K)/Akt signaling, leading to the inhibition of glycogen synthase kinase-3β and the nuclear translocation of β-catenin, followed by the increase of the transcriptional activity by β-catenin/T-cell factor complex formation in both SaOS-2 cells and MC3T3-E1 cells.

Sphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that involves in numerous pathophysiological processes. Endothelial progenitor cells (EPCs) play a crucial role in endothelial repair and tumor angiogenesis. The aim of study was to determine the effects of S1P on proliferation and anti-a …

2023年8月10日 · After acting on the S1P receptor, S1P can activate the downstream PI3K/Akt signaling pathway and play an anti-cerebral ischemia role. Buyang Huanwu Decoction (BHD) is a traditional Chinese medicine formula used to treat ischemic stroke.

2020年5月18日 · Stimulation of osteoblasts with S1P increased mRNA and protein expression of IL-6. PI3K, MEK, ERK and NF-κB inhibitors and their small interfering RNAs (siRNAs) reduced S1P-promoted IL-6 expression. S1P also facilitated …

在细胞核中发现了含有S1P的HDAC复合物，可以阻止组蛋白中赖氨酸残基脱乙酰化，从而改变基因表达模式。 这种机制可以上调细胞周期调节蛋白p21的表达，而p21是细胞周期蛋白依赖性激酶（CDK）的抑制剂，参与p53介导的细胞凋亡。

2014年12月23日 · To assess the potential role of the S1P 1 receptor in regulating PI3K–Akt–FoxO3a axis in response to oxidative stress, we examined the mRNA expression levels as well as total and phosphorylated PI3K (Tyr 458/199), phosphorylated Akt (serine 473), and its downstream target phosphorylated FoxO3a (Ser318/321) protein levels in PC12 cells in ...

我们的结果表明，S1P的保护作用是通过激活PI3K / Akt途径介导的。 此外，观察到S1P促进EPCs增殖主要是通过S1PR3介导的，而H2O2诱导的EPCs凋亡的减弱主要是通过S1PR1介导的。

2023年12月31日 · S1P activates the PI3K/Akt signaling pathway, leading to nuclear translocation of β-linked protein in osteoblast-like cells and inducing osteoprotegerin gene expression in osteoblast-like cell lines [54].