2022年1月1日 · Whereas S1P processes a set of substrates independently of S2P, the latter acts in concert with S1P in a mechanism, called regulated intramembrane proteolysis, that controls …

在高尔基体，s1p 和 s2p 对 bzip 蛋白的切割都是必不可少的，尽管只能检测到 s2p 的切割产物。 一个可能的原因是，S1P 的切割是必要的第一步，能增强 S2P 的作用，S1P 一旦完成切 …

2023年6月3日 · Here, we show that the lipogenesis signal cascade Scap-SREBP1-S1P/S2P orchestrates the homeostasis and spatiotemporal activation of NF-κB. SREBP cleavage …

人类表达两种不同的SREBP，称为固醇调节元件结合转录因子1（SREBF1）和SREBF2。 哺乳动物的SREBF1有两种转录本， SREBP-1a 和 SREBP-1c （也称为adipocyte differentiation …

2020年5月8日 · SCAP is an endoplasmic reticulum (ER) sterol-sensing protein that chaperones SREBP-1 and SREBP-2 from the ER to the Golgi apparatus 2. In the Golgi, two proteases, …

s2p 是一类含锌的金属蛋白酶家族，也是最早 被发现具有膜内蛋白水解功能的蛋白酶家族，广泛 存在于古细菌、细菌和真核生物中，其参与的信号

Here, we review recent research on S2P cascades, including human S2P, E. coli RseP, B. subtilis SpoIVFB and the newly identified S2P homologs. We also discuss the variation and …

First, site-1 protease (S1P) cleaves SREBP in the luminal loop, producing an intermediate in which the N-terminal transcription factor remains attached to the membrane and a C-terminal …

Whereas S1P processes a set of substrates independently of S2P, the latter acts in concert with S1P in a mechanism, called regulated intramembrane proteolysis, that controls lipid …

2021年7月20日 · Sterol regulatory element-binding protein-1 (SREBP1) is cleaved by site 1 protease (S1P) to release the transcriptionally active amino-terminal domain. PF-429242 is a …