2024年12月25日 · S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P2, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). [5] This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation. [5] .

S1PR2与G蛋白不同的α亚基耦联激活不同的信号途径而发挥不同的生物学功能，已证明S1PR2主要结合Gαi、Gαq和Gα12/13蛋白 。目前认为，S1PR2能够首先激活Gα12/13途径来调节多种关键细胞内信号通路，诸如Rho GTP酶和Rho相关蛋白激酶ROCK，还可抑制Rac途径，抑制细胞的 ...

2024年4月25日 · 我们首先总结了s1pr2的结构和生物学功能及其在人类疾病中的病理作用。 然后我们重点关注 S1PR2 调节剂的发现方法、设计策略、开发过程和生物医学应用。

We first summarize the structure and biological function of S1PR2 and its pathological role in human diseases. We then focus on the discovery approach, design strategy, development process, and biomedical application of S1PR2 modulators. Additionally, we outline the major challenges and future directions in this field.

S1PR2 is a key regulator of the proinflammatory phenotype of the endothelium. S1PR agonists are pro-fibrotic via S1P2R and S1P3R stimulation using Smad-independent pathways. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways

2024年4月25日 · We first summarize the structure and biological function of S1PR2 and its pathological role in human diseases. We then focus on the discovery approach, design strategy, development process, and biomedical application of S1PR2 modulators.

2013年7月18日 · Endothelial S1PR2 plays a critical role in the induction of vascular permeability and vascular inflammation during endotoxemia. S1PR2 could be a novel therapeutic target to promote vascular integrity in inflammatory vascular disorders. The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation.

Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules that are ubiquitously expressed in the human body and play an important role in the immune system. S1P-S1PR signaling has been well characterized in immune trafficking and activation in both innate and adaptive immune systems.

用于研究常染色体隐性遗传性非综合征性耳聋 68 和非霍奇金淋巴瘤。 该基因的人类直向同源基因与常染色体隐性非综合征性耳聋 68 相关。 与人类 S1PR2（1-磷酸鞘氨醇受体 2）直向同源。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation and sphingosine-1-phosphate receptor signaling pathway.