p70核糖体s6激酶 (s6k) 和真核起始因子eif4e的结合蛋白 4ebp。它们各自通过下游的效应子来分别促进帽依赖的翻译及ejc相关的翻译。其中s6k的激活会磷酸化并降解胰岛素受体底物irs1，从而形成了一个负反馈调节。 （2）脂质、核苷酸及葡萄糖代谢

Akt 激活后可通过抑制 GSK-3 诱导糖原合成；通过 mTOR 和下游成分进行蛋白质合成；通过抑制多个促凋亡因子（Bad、FoxO 转录因子、GSK-3 和 MST1）促进细胞存活。

2011年11月11日 · Here we provide evidence for two mechanisms of modulating turn motif phosphorylation and S6K1 activity. First, mammalian target of rapamycin regulates turn motif phosphorylation by inhibiting its dephosphorylation. Second, we unexpectedly found that glycogen synthase kinase (GSK)-3 promotes turn motif phosphorylation.

2020年4月1日 · GSK-inactivating kinases include Akt, 90-kDa ribosomal S6 kinase (p90RSK), 70-kDa ribosomal S6 kinase 1 (p70S6K1), and protein kinase A (PKA) [18]. In contrast, the two tyrosine residues are believed to be autophosphorylated by GSK3 itself, although there are reports showing that other kinases could be involved, including mitogen-activated ...

2011年11月22日 · The p70 ribosomal protein S6 kinase 1 (S6K1) plays a key role in cell growth and proliferation by regulating insulin sensitivity, metabolism, protein synthesis, and cell cycle. Thus, deregulation of S6K contributes to the progression of type 2 …

The GSK-3 signaling pathway was reported to regulate autophagy flux via the mTORC1, PKC and AKT signaling pathways [30,61,65,78,111]. mTORC1, known as a major autophagy regulator, is involved in the phosphorylation and inhibition of GSK-3β via its substrate, S6K [58,59].

A rapamycin-sensitive pathway, most likely acting via ribosomal 70-kDa protein S6 kinase (p70(S6K)), has also been implicated in the regulation of GSK-3 and GS by insulin. Amino acids potently stimulate p70(S6K), and recent studies on cultured muscle cells suggest that amino acids also inactivate GSK-3 and/or activate GS via activating p70(S6K).

Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of...

thase kinase (GSK)-3 promotes turn motif phosphorylation. Our studies show that mammalian target of rapamycin and GSK-3 cooperate to control the activity of S6K1, an important regulator of cell proliferation and growth. Our unexpected results provide a clear rationale for the development and use of drugs targeting

2022年7月25日 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been canonically assigned for cell...