SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene. [5] It is a dimeric/tetrameric transcription factor [6] with multiple DNA binding domains (CUT1, CUT2 and a Homeobox domain).

2024年12月25日 · SATB1 (SATB Homeobox 1) is a Protein Coding gene. Diseases associated with SATB1 include Den Hoed-De Boer-Voisin Syndrome and Developmental Delay With Dysmorphic Facies And Dental Anomalies. Among its related pathways are Transport of the SLBP independent Mature mRNA and Programmed Cell Death.

2024年10月11日 · SATB1 regulates higher-order chromatin organization and enhancer-promoter interactions at the CC chemokine locus to ensure their proper expression in T cells, thereby protecting organs from...

2018年11月9日 · This review highlights cellular and molecular events governed by SATB1 influencing the structural organization of chromatin and interacting with several co-activators and co-repressors of ...

2016年1月15日 · Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer that is expressed by T cells. T cell development is severely impaired in SATB1 null mice; however, because SATB1 null mice die by 3 wk of age, the roles of SATB1 in T cell development have not been well clarified.

2020年7月16日 · satb1是一种著名的sidd调节蛋白，主要在发育中的t细胞，表皮和滋养层干细胞（tscs）中表达。satb1与sidd结合，然后稳定dna双螺旋，从而建立并维持大规模的常染色质和异染色质结构域。

2023年4月25日 · Special AT-rich sequence binding protein 1 (SATB1) is an inner nuclear protein that has long been implicated in genome organization. 14, 15, 16, 17, 18, 19, 20 SATB1 is most highly expressed in T cells and plays an essential role during T cell development by directing lineage-specifying transcriptional programs for CD4 + T, CD8 + T, Foxp3 ...

2018年3月28日 · Satb1-null mice, characterized by a total Satb1-knockout, show numerous defects in T cell development. Furthermore, they display a small thymus and spleen and show neuronal defects as well as epidermal alterations. Satb1-null mice are considerably smaller than comparable wildtype mice and usually survive for only three weeks [50]. In another ...

2020年6月10日 · Satb1 is predominantly expressed during the double positive stage of T cell development, indicating a potential role of SATB1 at this stage. Important master regulators and key events of the T cell development are also depicted to better understand the processes and the genes which SATB1 could regulate.

SATB 同源框 1： 该基因编码一种基质蛋白，该蛋白通过独特的核结构结合核基质和支架相关 DNA。该蛋白质募集染色质重塑因子以调节染色质结构和基因表达。[RefSeq 提供，2016 年 4 月]