2024年4月11日 · The suprachiasmatic nucleus (SCN) is the mammalian central circadian pacemaker with heterogeneous neurons acting in concert while each neuron harbors a self-sustained molecular...

The suprachiasmatic nucleus or nuclei (SCN) is a small region of the brain in the hypothalamus, situated directly above the optic chiasm.

2020年2月17日 · We have used single-cell RNA-sequencing to identify the basic cell types in the mouse SCN and to characterize their circadian and light-induced gene expression patterns. We identified eight...

In this review, we will discuss the function of the SCN as a master circadian pacemaker tissue, focusing on cell autonomy and network properties. The circadian clock that operates in mammalian cells is based on delayed negative feedback (18) in a …

2018年8月6日 · In this primer, we shall briefly review the historical identification of the SCN as the master circadian clock, and then discuss it on three different levels: the cell-autonomous SCN, the SCN as a cellular network and, finally, the SCN as circadian orchestrator.

2018年6月22日 · Formal, non-genetic analysis of network topology (for example, by analysing shared information metrics between cells) has identified a small-world suprachiasmatic nucleus (SCN) network (see the...

A genetically encoded clock drives self-sustained circadian rhythmicity in individual cells. Intercellular coupling in the SCN coordinates cell-autonomous rhythms into a coherent and resilient circadian pacemaker that tunes all the body rhythms. Green and blue cells depict SCN neurons and astrocytes, respectively.

2020年8月7日 · In mammals, the hypothalamic suprachiasmatic nucleus (SCN) acts as a master pacemaker controlling circadian rhythms in behavioral states (sleep-wake), feeding behavior, body temperature, and endocrine physiology (Hastings et …

2003年9月30日 · In mammals, the suprachiasmatic nucleus (SCN) contains a biological clock that drives circadian rhythms in vivo and in vitro. Primary dissociated neuronal culture is a useful research tool, which allows cell-by-cell morphological and physiological study of the SCN.

2020年2月18日 · We have used single-cell RNA-sequencing to identify the basic cell types in the mouse SCN and to characterize their circadian and light-induced gene expression patterns. We identified eight major cell types, with each type displaying a …