SCP3是突触复合体（synaptonemal complex）的组分，在减数分裂前期的同源染色体间形成。 该蛋白在雄性生殖细胞减数分裂期着丝粒配对时发挥作用。 精子发生和雄性生育能力期间正常的减数分裂需要SCP3的参与。

2024年12月25日 · SYCP3 (Synaptonemal Complex Protein 3) is a Protein Coding gene. Diseases associated with SYCP3 include Spermatogenic Failure 4 and Male Infertility. Among its related pathways are Meiosis and Cell Cycle, Mitotic. An important paralog of this gene is FAM9A.

We propose that SCP3 fibers constitute the core of the lateral elements of the synaptonemal complex and function as a molecular framework to which other proteins attach, regulating DNA binding to the chromatid axis, sister chromatid cohesion, synapsis, and recombination. Keywords: meiosis, cohesion, lateral element, chromosomes, recombination.

2024年9月11日 · Special Containment Procedures: Any attempts to fully contain SCP-3 would require the complete dissolution of the entire Foundation; thus, it must be allowed to propagate as it has since the inception 2 of this organization. Description: SCP-3 …

2025年2月8日 · Positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival. mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction.

Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

2001年4月16日 · SYCP3 localizes to the lateral elements of the synaptonemal complex and is essential for male meiosis. The genomic structure of SYCP 3 consists of nine exons spanning approximately 14 kb. In mouse and rat, but not in hamster, the putative translation start of SYCP 3 is present in the first exon.

SCP-3抗体（D-1）是一种IgG1 κ小鼠单克隆SCP-3抗体（也称为联会复合体蛋白3抗体、SCP3抗体、RPRGL4抗体、SPGF4抗体或COR1抗体），它通过WB、IP、IF、IHC (P)和ELISA检测小鼠和大鼠来源的SCP-3蛋白。 SCP-3抗体（D-1）以非偶联的抗SCP-3抗体形式以及多种偶联形式的抗SCP-3抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。 联会复合体是减数分裂特有的核细胞器，参与染色体重排，如减数分裂前期的染色体配对和重组。 SCP-2 …