2024年1月10日 · The use of ECAP-based SCS dose implemented in ECAP-controlled CL-SCS produced analgesia in animals subjected to an experimental model of neuropathic pain. This approach may offer a better method for translating SCS parameters between species that will improve understanding of the mechanisms of SCS action to further advance future clinical ...

2024年5月7日 · The aim of this study was to determine whether evoked compound action potential (ECAP)-controlled, closed-loop SCS (CL-SCS) is associated with better outcomes when compared with fixed-output, open-loop SCS (OL-SCS) 36 months following implant.

In this report, we provide perspective on a new direction for spinal cord stimulation that unites the latest therapeutic paradigms with one of the newer SCS technologies available—CL control using the spinal evoked compound action potential (ECAP) as a feedback control variable.

2021年5月2日 · Closed‐loop SCS based on ECAP measurements provides objectivity during programming and the avoidance of over and understimulation as the stimulation level stayed in the therapeutic window more than 90% of the time on average. Alternative SCS systems are trying to address overstimulation by exploring sub‐perception stimulation paradigms.

Here, we present the final 24-month results of the Avalon study, which investigated the use of the first closed-loop SCS system in patients with chronic pain. The system measures the evoked compound action potentials (ECAPs) elicited by each stimulus pulse and drives a feedback loop to maintain the ECAP amplitude near constant.

2022年11月11日 · Neural activation differences between burst and conventional SCS are quantifiable with the spinal-evoked compound action potential (ECAP), an electrical measure of synchronous neural activation.

2024年10月1日 · Physiologic Closed-Loop Control (PCLC) technology for treating chronic pain is based on over 10-years of rigorous research and development with the first measurement of ECAPs in the human spinal cord in chronic pain patients undergoing spinal cord stimulation (SCS) reported by Parker et al. in 2012 1. At present, few such systems exist owing to ...

2021年7月11日 · Recent technological advances have enabled sensing of the evoked compound action potential (ECAP), a biopotential that represents neural activity elicited from SCS. The amplitudes of many SCS paradigms – both sub- and supra-threshold – are programmed relative to the patient’s perception of SCS.

本研究的目的是确定诱发复合动作电位 (ECAP) 控制的闭环 SCS (CL-SCS) 与固定输出开环 SCS (OL-SCS) 相比是否与更好的结果相关36植入后几个月。 方法 EVOKE 研究是一项多中心、参与者盲法、研究者盲法和结果评估者盲法、随机、对照、平行臂临床试验，比较 ECAP 对照 CL-SCS 与固定输出 OL-SCS。 2017 年 1 月至 2018 年 2 月期间，招募了患有保守治疗难治的慢性顽固性背部和腿部疼痛的参与者，并随访了 36 个月。 主要结果是整体背部和腿部疼痛减轻至少 …

2024年1月10日 · The evoked compound action potential (ECAP) represents a measure of dorsal column fiber activation. This measure approximates the onset of SCS-induced sensations in humans and provides effective analgesia when used …