2021年10月12日 · Herein, we investigate whether stromal cell-derived factor (SDF)-1 secreted by MSCs contributes to EPC migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases (PI3K)/protein kinase B (termed as AKT) signaling pathway.

2014年7月1日 · A key receptor in MSC homing to the ischemic myocardium is CXCR4, a chemotactic receptor recognizing the chemokine stromal-derived factor-1 (SDF-1). Expression of SDF-1 in the ischemic myocardium is immediately up regulated after infarction and the increased SDF-1 expression facilitates the recruitment of CXCR4-positive cells [11] .

2017年9月8日 · Homing of peripheral stem cells is regulated by one of the most representative homing factors, stromal cell-derived factor 1 alpha (SDF-1α), which specifically binds to the plasma membrane receptor CXCR4 of mesenchymal stem cells (MSCs) in order to initiate the signaling pathways that lead to directional migration and homing of stem cells.

Conclusions: Collectively, our study speculated that up-regulation of SDF-1 promotes the mobilization and migration of MSCs through the activation of the SDF-1/CXCR4 signal pathway. Keywords: Bone defect; Bone graft; Induced membrane technique; SDF-1/CXCR4 axis; Stromal cell-derived factor-1.

Introduction: Stromal cell-derived factor-1α (SDF-1) is a chemokine that plays a major role in cell trafficking and homing of CD34 (+) stem cells. Studies employing SDF-1/CXCR4 have demonstrated its therapeutic potential in tissue engineering.

Herein, we investigate whether stromal cell-derived factor (SDF)-1 secreted by MSCs contributes to EPC migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases (PI3K)/protein kinase B (termed as AKT) signaling pathway.

2019年1月3日 · vec是血管结构的重要组成部分,目前针对sdf-1的研究主要集中于其趋化作用，而sdf-1对msc向vec分化的影响尚未有深入探索。本实验通过添加不同剂量的sdf-1或联合vegf干预，探究sdf-1对bmsc向vec分化的影响。

在这里，我们评估了 sdf-1-cxcr4/cxcr7 通路在体外和体内调节 hp-mscs 的趋化性、活力和旁分泌作用中的作用。 与常氧预处理 (NP) 相比，HP 不仅提高了 MSC 的趋化性和活力，还刺激了促血管生成和有丝分裂因子的分泌。

Several phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) stimulators including SDF-1 have been shown to increase MSC migration . SDF-1-enhanced MSC migration was mediated through the activation of the PI3K/Akt pathway .

2022年2月23日 · The SDF-1/CXCR4 axis mediates MSC migration, and the activation of the ERK 1/2 downstream signalling pathway induced by the binding of SDF-1 to CXCR4 was required for MSC migration .