SERCA is a P-type ATPase. [1] It resides in the sarcoplasmic reticulum (SR) within myocytes. [1] It is a Ca 2+ ATPase that transfers Ca 2+ from the cytosol of the cell to the lumen of the SR. …

2023年6月8日 · SERCA2 is phosphorylated at serine 663 in both mouse and human hearts. The cardiac isoform 2 of the sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA2) plays a major …

2024年12月24日 · Stabilizes SERCA2 in its E2 state (PubMed:28890335). AT2A2_HUMAN,P16615; Molecular function for ATP2A2 Gene according to GENATLAS. …

Intriguingly, SERCA2-dependent Ca 2+ dysregulation has been implicated in several disorders that affect cognitive function, including Darier's disease, schizophrenia, Alzheimer's disease, …

2018年4月16日 · The current review summarizes knowledge on the expression pattern of the different SERCA2 isoforms in the nervous system, and further discusses evidence of SERCA2 …

Calcium ion (Ca²⁺) cycle plays a crucial role in the contraction and relaxation of cardiomyocytes. The sarcoplasmic reticulum (SR) acts as an organelle for storing …

2024年12月17日 · SERCA2 dysregulation has been implicated in several disorders including schizophrenia, Alzheimer’s disease, and cerebral ischemia. 62 For example, studies in …

SERCA2 is the principal subtype of SERCA in the vasculature, responsible for maintaining calcium homeostasis by transporting Ca 2+ from the cytoplasm to the ER lumen. The major …

2020年5月15日 · 多项研究证明SERCA2a能够发生PTM，并且可在不同位点发生不同类型的PTM，从而影响SERCA2a的活性及功能。 蛋白质磷酸化是指在蛋白激酶的作用下，将磷酸基 …

2018年2月21日 · The SERCA2 gene is best known for encoding both the ubiquitous and cardiac-specific isoforms of SERCA (Vangheluwe et al. 2005). In all, four isoforms (SERCA2a-d) are …