In this review, I summarize and discuss our current understanding of the function of the serine/threonine kinase SGK1 as a downstream effector of PI3K, and try to separate targets and pathways validated as uniquely SGK1-dependent from those shared with AKT.

2018年7月23日 · SGK is a family of serine/threonine kinases involved in the regulation of many cellular processes including cell growth and survival downstream of PI3K, and is...

In this review, I summarize and discuss our current understanding of the function of the serine/threonine kinase SGK1 as a downstream effector of PI3K, and try to separate targets and pathways validated as uniquely SGK1-dependent from those shared with AKT. 1. INTRODUCTION: THE GLUCOCORTICOIDREGULATED KINASE FAMILY.

2017年1月1日 · In this review, I summarize and discuss our current understanding of the function of the serine/threonine kinase SGK1 as a downstream effector of PI3K, and try to separate targets and pathways validated as uniquely SGK1-dependent from those shared with AKT. 1. Introduction: The Glucocorticoid-Regulated Kinase Family.

2018年9月1日 · The serum and glucocorticoid inducible protein kinase (SGK) family signals downstream of the PI3K pathway, and shares similar structure, substrate specificity and function with AKT. Like AKT, SGK is involved in the regulation of cell proliferation and survival.

2017年12月12日 · In particular, SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations. Notably, co-targeting SGK1 and AKT resulted in significantly higher growth suppression than inhibiting either PI3K or AKT alone.

2019年4月2日 · Here, we show that PI3Kα inhibition, via a negative-feedback loop, activates SGK1 to promote chromatin-based regulation of ER-dependent transcription. PI3K/AKT inhibitors activate ER, which promotes SGK1 transcription through direct binding to its promoter.

2016年8月8日 · Here we show that in cancer cells resistant to PI3Kα inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2.

Upon full activation, SGK1/3 phosphorylates its substrates with an optimal consensus motif of R-X-R-X-X-S/T to regulate cellular processes including cell growth, proliferation, migration, invasion, and resistance to PI3K and AKT inhibitors. Activation of SGK signaling has also recently emerged as an important mechanism of resistance to PI3K and ...

The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell p …