Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene. SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids .

2024年12月25日 · SGK1 (Serum/Glucocorticoid Regulated Kinase 1) is a Protein Coding gene. Diseases associated with SGK1 include Gastric Cancer and Pseudohypoaldosteronism. Among its related pathways are Gene expression (Transcription) and Regulation of …

2024年10月1日 · Multiple research findings have indicated that SGK1 is associated with heart disease due to its involvement in cardiac hypertrophy and fibrosis. This article reviews different signaling pathways associated with SGK1 activity in various heart conditions, including the SGK1/NF-κB and PI3K/SGK1 pathways. 1. Introduction.

该基因编码在细胞应激反应中起重要作用的丝氨酸/苏氨酸蛋白激酶。 这种激酶激活某些钾、钠和氯通道，表明参与细胞存活、神经元兴奋性和肾钠排泄等过程的调节。 这种酶被蛋白质磷酸 …

血清和糖皮质激素诱导蛋白激酶 (SGKs)是一种AGC家族的丝氨酸苏氨酸蛋白激酶,其包括位于不同染色体的三个基因编码的蛋白激酶 (SGK1,SGK2,SGK3). SGKs主要由磷脂酰肌醇-3-激酶 ( PI3K)激活,通过磷酸化下游的靶蛋白调控细胞的生长,神经元兴奋性,肾钠排泄等. SGK1作为PI3K通路主要的调节靶点,不仅参与离子转运,T细胞活化,炎症抑制,脂肪细胞分化,还在心肌细胞纤维化,血管钙化,炎症性肠病,自噬抑制,结直肠癌及多形胶质母细胞瘤等多种临床生理和病理过程中起重要作用.

Serum and glucocorticoid-regulated kinase 1 (SGK1) is a member of the protein kinase A, G, and C (AGC) family (Firestone et al., 2003). SGK1 was first identified in rat mammary gland tumor cells in response to serum/glucocorticoid stimulation, and its expression has been detected in all tissues (Webster et al., 1993).

2021年1月19日 · This review systematically summarizes and discusses the role of SGK1 as a diagnostic and prognostic biomarker of diverse cancer types; focuses on its essential roles and functions in tumorigenesis, cancer cell proliferation, apoptosis, invasion, metastasis, autophagy, metabolism, and therapy resistance and in the tumor microenvironment; and ...

2022年6月1日 · Serum- and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that plays important roles in the cellular stress response. While SGK1 has been reported to restrain inflammatory immune responses, the molecular mechanisms involved remain elusive, especially in oral bacteria-induced inflammatory milieu.

2020年7月15日 · The functions of SGK1 include regulating tumor growth, survival, metastasis, autophagy, immunoregulation, calcium (Ca 2+) signaling, cancer stem cells, cell cycle, and therapeutic resistance. In this review, we introduce the pleiotropic role of SGK1 in the development and progression of tumors, summarize its downstream targets, and integrate ...

研究人员给予了小鼠Sgk1特异性抑制剂GSK650394，并观察到高磷酸化tau蛋白水平显著降低，前额叶皮层谷氨酸能突触的功能发生恢复，AD小鼠的记忆障碍也得到了改善。