SGK1 appears to promote oncogenic signaling aimed at preserving the survival and fitness of cancer cells. Most importantly, recent investigations have revealed the ability of SGK1 to skew immune-cell differentiation toward pro-tumorigenic phenotypes.

2024年12月25日 · SGK1 (Serum/Glucocorticoid Regulated Kinase 1) is a Protein Coding gene. Diseases associated with SGK1 include Gastric Cancer and Hematologic Cancer. Among its related pathways are Gene expression (Transcription) and Regulation of …

2023年6月24日 · A study illustrated that under high NaCl conditions, SGK1 expression in Tregs using special SGK1-shRNA resulted in decreased production of IFN-γ and restored its function, elucidating that elevated salt concentration suppressed Foxp3 + …

SGK1 negatively regulates the pro-apoptotic transcription factor Forkhead box O3a (FoxO3a) via phosphorylation and exclusion from the nucleus. Hsp90 activity is essential for regulating the PI3K/SGK-1 pathway. SGK1 is an mTOR-raptor substrate and mTOR may promote G1 progression in part through SGK1 activation and deregulate the cell cycle in ...

2021年1月19日 · This review systematically summarizes and discusses the role of SGK1 as a diagnostic and prognostic biomarker of diverse cancer types; focuses on its essential roles and functions in tumorigenesis, cancer cell proliferation, apoptosis, invasion, metastasis, autophagy, metabolism, and therapy resistance and in the tumor microenvironment; and ...

2011年4月11日 · SGK1, which has been shown to be involved in cellular proliferation and apoptosis protection, is a serine/threonine kinase of the AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase...

Serum and glucocorticoid-regulated kinase 1 (SGK1) is a member of the protein kinase A, G, and C (AGC) family (Firestone et al., 2003). SGK1 was first identified in rat mammary gland tumor cells in response to serum/glucocorticoid stimulation, and its expression has been detected in all tissues (Webster et al., 1993).

2020年7月15日 · In this review, we introduce the pleiotropic role of SGK1 in the development and progression of tumors, summarize its downstream targets, and integrate the knowledge provided by preclinical studies that the prospect of SGK1 inhibition as a potential therapeutic approach.

The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a key-regulator of transport, cell volume and cell survival. SGK1 transcription is under genomic control of a wide variety of hormones and cell stressors. Little is known, however, …

研究人员给予了小鼠Sgk1特异性抑制剂GSK650394，并观察到高磷酸化tau蛋白水平显著降低，前额叶皮层谷氨酸能突触的功能发生恢复，AD小鼠的记忆障碍也得到了改善。