2002年7月1日 · In this report, we describe the antiproliferative activities of the mouse antihuman CD30 mAb AC10 (20) on HD cells and the antitumor activity of SGN-30, a chimeric antibody derived from AC10.

The unconjugated cAC10 antibody SGN-30 (Wahl et al, 2002) and SGN-35 are both under evaluation in clinical trials for the treatment of CD30-positive haematological malignancies, including ALCL and HL (Schnell & Borchmann, 2006).

SGN-30, a chimeric monoclonal antibody with apoptotic-signaling activity against CD30-positive malignancies, is currently in Phase II clinical evaluation against anaplastic large cell lymphoma...

SGN-30, a monoclonal antibody with activity against CD30+ malignancies, is currently in phase II clinical evaluation for treatment of Hodgkin's disease (HD) and anaplastic large cell lymphoma.

2002年7月1日 · SGN-30 is being developed for the treatment of patients who have HD that is refractory to initial treatment or who have relapsed and have limited therapeutic options and is able to inhibit the growth of HD cell lines in vitro.

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SGN-30, a monoclonal antibody with activity against CD30+ malignancies, is currently in phase II clinical evaluation for treatment of Hodgkin's disease (HD) and anaplastic large cell lymphoma. The mechanisms underlying SGN-30's antitumor activity were investigated using cDNA array of …

2002年7月1日 · SGN-30 is being developed for the treatment of patients who have HD that is refractory to initial treatment or who have relapsed and have limited therapeutic options. The leukocyte activation marker CD30 is highly expressed …

SGN-30 is being developed for the treatment of patients who have HD that is refractory to initial treatment or who have relapsed and have limited therapeutic options. The leukocyte activation marker CD30 is highly expressed on the Reed Sternberg cells of Hodgkin’s disease (HD).

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