Methods and results: Using deletion mutants of the virus and measuring IL-1β secretion, as well as caspase 1 expression via western blotting, we demonstrate that the NLRP3 inflammasome …

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation. Background Respiratory syncytial virus (RSV) remains the …

2019年2月5日 · Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. Although the virus was isolated in 1955, an...

2024年12月18日 · This study elucidated the mechanism by which MARCH8 restricts respiratory syncytial virus (RSV) replication through selective degradation of the viral small hydrophobic …

2016年11月5日 · Our results reinforce the key role of SH protein in the cellular homeostasis control during viral infection and in interactions with viral and host proteins. This viral strategy …

2011年12月13日 · The small hydrophobic (SH) protein is encoded by the human respiratory syncytial virus. Its absence leads to viral attenuation in the context of whole organisms, and it …

宿主信号炎症小体激活。我们证明 nlrp3 炎症小体是通过小的疏水性 (sh) rsv 病毒孔蛋白激活的，该病毒孔蛋白诱导膜对离子或小分子的渗透。共聚焦显微镜显示，在病毒感染期间，sh 似 …

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