Jan 13, 2018 · Good question. First let's recognize that thiols (-SH) are more acidic functional groups than the corresponding alcohols (-OH) (some rationale here). So if we were talking …

Aug 11, 2015 · For both the first and second ionizations, the difference in electron withdrawing power is enough to lower the pKa by >1 pKa unit. iad22agp's explanation is a good way of …

Nov 27, 2013 · For this, you can use the Henderson-Hasselbalch equation.Using the degree of dissociation, $\alpha$, this can be written as $$\mathrm{pH} = \mathrm{p}K_\mathrm{a} + …

Aug 4, 2023 · $\ce{H3C–SH}$: 10.4 $\ce{H3C–C(O)–OH}$: 4.8. This comparison clearly indicates that the carboxylic acid group imparts stronger acidity than the thiol group. The determinimg …

Feb 22, 2015 · For OH and SH functional groups in proteins, when $\ce{pH}>\ce{p}K_a$, then the group is deprotonated and has a negative charge. For amino groups, $\ce{HA}$ is …

May 2, 2015 · The acid being used has a pKa value; So titrating acetic acid (pKa = 4.76) with NaOH, then phenolphthalein (pka = 10) is a good indicator to use since it will be colored after …

Nov 28, 2020 · Cysteine amino acid has an embedded sulfur group in its side chain. Looking at the electronegativity difference of hydrogen and sulfur, it can be considered a non-polar side …

Nov 6, 2014 · Phenol has a $\\mathrm pK_\\mathrm a$ approximately equal to $9.9$. When one studies the acidity of chlorophenols, one notices the following: First of all, chlorophenols are …

Nov 4, 2022 · I try to predict pKa values of acids (in water), computing their energy of deprotonation with quantum chemistry; and I found that the slope of the linear correlation "pK …

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