SH3-domain-containing proteins function at distinct steps in
1999年5月15日 · Here we report the efficient reconstitution of ATP-, GTP-, cytosol- and dynamin-dependent formation of clathrin-coated vesicles in permeabilized 3T3-L1 cells. The SH3 …
Protein context shapes the specificity of SH3 domain-mediated ... - Nature
2021年3月12日 · We show that the identity of the host protein and the position of the SH3 domains within their host are critical for PPI specificity, for cellular functions and for key …
SH3 domain - Wikipedia
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v …
SH3功能域 - 百度百科
络氨酸磷酸化是调节接头结构域（adaptor domains）活性的一种重要机制。络氨酸的磷酸化能够促进 信号蛋白 通过SH2或PTB结构域来相互作用，但是SH3结构域的磷酸化作用却不然，它反 …
SH3 蛋白结构域 | 脯氨酸富集基序 | Cell Signaling Technology
结合 mSOS 肽（红色）的 SEM-5 的羧基末端 SH3 结构域。 S rc- 同源 3 (SH3) 结构域结合脯氨酸富集肽，这种肽会与最小的共有 Pro-X-X-Pro 形成左侧聚脯氨酸 II 型螺旋。 脂肪族残基通常 …
SH3结构域 - 维基百科，自由的百科全书
SH3结构域（英語： SH3 domain ，全称Src同源3结构域，英語： SRC Homology 3 Domain ）是最早在病毒 接头蛋白v-Crk及酪氨酸激酶 Src、Abl中发现的长约60个氨基酸残基的保守 结构 …
Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron ...
2019年8月21日 · Here, we present the atomic model of the PI3K-SH3 amyloid fibril with a resolution determined to 3.4 Å by cryo-electron microscopy (cryo-EM). The fibril is composed …
SH结构域(SH domain) - 知乎 - 知乎专栏
2023年12月7日 · SH3能够识别富含脯氨酸和 疏水残基 的特异序列的蛋白质并与之结合,从而介导蛋白与蛋白相互作用。 SH结构域是“Src同源结构域” (Src homology domain)的缩写 (Src是一 …
SH3 domains: modules of protein–protein interactions - PMC
Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a …
Structure and function of the SH3 domain - ScienceDirect
1994年1月1日 · The structures of the SH3 domains from PLC-y (Kohda et al., 1993), Src (Yu et al., 1992, 1993), and the p85 subunit of PI-3 kinase (Koyama et al., 1993a,b; Booker et al., …