Signaling via Shc family adapter proteins | Oncogene - Nature
2001年10月17日 · The SH2 domain of Shc, which is located at its very C-terminus, was initially characterized as a domain responsible for its recruitment to the activated epidermal growth …
肿瘤生物学：（5）癌症中的细胞信号网络 - 知乎
SH2和SH3结构域解释了生长因子受体如何激活Ras并获得信号传递的特异性。 Grb2包含两个SH3结构域和一个SH2结构域，它的SH3结构域对Sos中两个不同的富含脯氨酸的序列具有亲 …
Shc研究深度剖析：探索原癌基因家族的奥秘
2024年12月18日 · Shc家族蛋白在结构上具有特有的高度保守结构域，即PTB-CH1-SH2：N端磷酸化酪氨酸结合区（PTB）、中央脯氨酸富集区1（CH1）和C端Src同源区2（SH2）。此外， …
SH2 domain - Wikipedia
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein [2] and in many other intracellular signal-transducing proteins. [3] SH2 …
A novel transforming protein (SHC) with an SH2 domain is
1992年7月10日 · A new SH2-containing sequence, SHC, was isolated by screening cDNA libraries with SH2 representative DNA probes. The SHC cDNA is predicted to encode …
Cloning and characterization of mPAL, a novel Shc SH2 domain
1999年3月15日 · Using the yeast two-hybrid system, we have identified a unique Shc binding protein designated PAL (P rotein expressed in A ctivated L ymphocytes) with no similarity to …
SHC2 Gene - SHC Adaptor Protein 2
2024年12月25日 · SHC2 (SHC Adaptor Protein 2) is a Protein Coding gene. Diseases associated with SHC2 include Borrelia Miyamotoi Disease. Among its related pathways are MAPK family …
SH2 蛋白结构域 | 磷酸化酪氨酸结合 | Cell Signaling Technology
S rc-同源 2 (SH2) 结构域是约含 100 个氨基酸的模块，可结合包含磷酸化 (pY) 的特异性肽基序。 常见 SH2 结构域有一个可识别 pY 的保守口袋、一个使含有 3-6 个羧基末端残基结合 pY 从而 …
SH2结构域 - 百度百科
SH结构域 是“Src同源结构域” (Src homology domain)的缩写 (Src是一种 癌基因,最初在Rous 肉瘤病毒 中发现)。 含有SH2结构域的 蛋白质 能够与其他蛋白质上的磷酸化 酪氨酸 残基 对接。 …
CDD Conserved Protein Domain Family: SH2_SHC - National …
SHC is composed of an N-terminal domain that interacts with proteins containing phosphorylated tyrosines, a (glycine/proline)-rich collagen-homology domain that contains the phosphorylated …