HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK…
2019年3月21日 · Detailed studies reveal that HoxA10 binds to p38 MAPK, recruits SH2-containing protein tyrosine phosphatase 1 (SHP-1) to facilitate SHP-1 in catalyzing …
Phosphatase SHP-1 promotes TLR- and RIG-I-activated …
2008年4月6日 · SHP-1 inhibited TLR-initiated production of proinflammatory cytokines by suppressing the activation of MAPKs and NF-κB, but it increased TLR- and RIG-I-activated …
SHP-1–Pyk2–Src Protein Complex and p38 MAPK Pathways …
2013年9月1日 · SHP-1 expression was analyzed by Western immunoblotting of protein lysates from control macrophages treated with either SHP-1 scrambled or SHP-2 specific ODNs using …
蛋白酪氨酸磷酸酶SHP-1在细胞信号系统中的负调控作用 - 丁香园
2013年1月21日 · SHP-1 作为 PTP 中重要的一员，是改变胞内磷酸化水平的关键因子，当外源性信号分子同胞膜上受体结合后激发受体分子二聚化，与受体耦联的两面神激酶（JAK）互相靠 …
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK …
The non-receptor protein tyrosine phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein kinase (MAPK) signaling during normal …
HoxA10通过反馈调节机制促进p38 MAPK / STAT3的SHP-1催化去 …
详细研究表明，hoxa10与p38 mapk结合，募集含有sh2的蛋白酪氨酸磷酸酶1（shp-1），以促进shp-1催化p38 mapk / stat3的去磷酸化，从而减弱p38 mapk / stat3的活化和hbv复制。此 …
FCRL3 promotes IL-10 expression in B cells through the SHP-1 ... - PubMed
These results suggest that FCRL3 can activate the SHP-1 and p38 MAPK pathways and then promote the secretion of IL-10 in B cells, thus inhibiting the secretion of inflammatory factors. …
SHP-1-Pyk2-Src protein complex and p38 MAPK pathways
2013年9月1日 · The results reveal that tyrosine kinases Src and proline-rich tyrosine kinase 2 (Pyk2) regulate SHP-1-dependent LPS-induced IL-10 production and infer that optimal LPS …
Effects of SHP-1 activation on MAPK phosphorylation levels: …
Download scientific diagram | Effects of SHP-1 activation on MAPK phosphorylation levels: Western blot analysis for phosphorylated MAPK (pMAPK) and total MAPK (tot MAPK) of …
Helicobacter pylori CagA Interacts with SHP-1 to Suppress the …
2021年3月15日 · Thus, CagA has emerged as a negative regulator of MAPK and NF-κB signaling pathways that functions by enhancing the recruitment of SHP-1 to TRAF6. In summary, we …