Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues. 启用 ATP 绑定活动；镁离子结合活性；和蛋白丝氨酸/苏氨酸激酶活性。 参与细胞内信号转导和蛋白质自身磷酸化。 预测位于核内。 预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月] Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity.

2024年12月25日 · SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Diseases associated with SIK2 include Pancreatic Cancer and Endometrial Cancer. Among its related pathways are Glucose / Energy Metabolism and LKB1 signaling events.

2025年1月1日 · Decreased SIK2 expression correlates with a poor prognosis in patients with HCC. Overexpression of SIK2 leads to reduced proliferation and invasion while increasing cell death via inactivation of the WNT–β-catenin pathway in HCC cells. Xenograft tumor models have revealed SIK2′s ability to suppress HCC cell growth.

2023年8月15日 · Salt-inducible kinase 2 (SIK2) has been recognized as a potential target for anti-inflammation and anti-cancer therapy. In this paper, based on the binding pose of the reported compound (GLPG-3970, 3) with AlphaFold protein structure, a series of hinge cores were generated via AI-generative models (Chemistry42).

SIK2 regulates CREB1 activity via the phosphorylation of TORC1 and its sequestration in the cytoplasm. The importance of SIK2 in prostate cancer cells growth and survival and the significant impact of the kinase-dead mutant on the cells phenotype implicate SIK2 and its downstream targets in prostate cancer progression.

2019年1月21日 · Activated sik2 phosphorylates Ser413 of the scaffold protein Salvador (Sav), a major part of the core kinase complex of the Hippo pathway, and subsequently abolishes the inhibition of the proto-oncogene Yki. In addition, sik2 directly induces the expression of Yki and facilitates Yki-dependent tissue overgrowth.

2024年5月1日 · We present four pharmacologically relevant and distinct SIK3-inhibitor complexes. These detail the key interaction for each ligand and reveal how different regions of the ATP site are engaged by the different inhibitors to achieve high affinity.

2012年6月6日 · SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kinases and is highly expressed in adipocytes. We investigated the regulation of SIK2 in adipocytes in response to cellular stimuli with relevance for adipocyte function and/or AMPK signalling.

Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and functions mainly involve in regulating energy response-related physiological processes, such as gluconeogenesis and lipid metabolism. The SIK family comprises three isoforms, namely, SIK1, SIK2, and SIK3, all of which may act as metabolic transmitters.

Studies focusing on ovarian and colon cancer have shown that SIK2 inhibition by miRNAs can effectively restore sensitivity in paclitaxel-resistant tumors, while lncRNAs and circRNAs that increase the activity of SIK2 can amplify tumor taxol resistance (49,51-53).