2013年8月22日 · Conversely, the protein deacetylase sirtuin 2 (SIRT2) deacetylates and destabilizes ACLY. Substitution of 3K abolishes ACLY ubiquitylation and promotes de novo …

2024年3月1日 · Currently, acetylation of ACLY at Lys-540, Lys-546 and Lys-554 makes ACLY more stable by antagonizing ACLY ubiquitination, and ACLY-3K acetylation can also promote …

在这项研究中，我们发现了 SIRT6 在控制 ACLY 和 ACLY 依赖性肿瘤抑制基因调控的核水平方面的新功能。 癌细胞中 SIRT6 的失活导致核 ACLY 蛋白的积累并增加核乙酰辅酶 A 库，进而驱 …

2024年3月1日 · sirt2抑制剂agk2可以抑制食道鳞状细胞癌的增殖和迁移，并增加acly蛋白质的乙酰化水平。 这些结果表明，SIRT2/ACLY信号轴的靶向治疗可能是食道鳞状细胞癌的潜在治疗策 …

2024年5月10日 · Ten DEGs associated with FAO were identified by RNA-Seq data, and ACLY, which generates acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis, was found …

Numerous studies have shown that lipid synthesis can be affected by regulating the acetylation state of ACLY through SIRT2 and P300/calcium-binding protein (CBP)-associated factor …

2024年11月15日 · Functional investigations demonstrated SIRT3’s regulation of benzoylated protein peptidyl-prolyl cis -trans isomerase F (PPIF), where K73bz and K197bz markedly …

The SIRT2 inhibitor AGK2 significantly increased the acetylation level of ACLY protein and inhibited the proliferation and migration of ESCC cells, while overexpression of ACLY partially …

2024年3月1日 · SIRT2抑制剂AGK2显着增加ACLY蛋白的乙酰化水平并抑制ESCC细胞的增殖和迁移，而ACLY的过表达部分逆转了AGK2对ESCC细胞的抑制作用。 总的来说，这些结果表明 …

ATP-citrate lyase (ACLY) is upregulated or activated in several types of cancer, and inhibition of ACLY arrests proliferation of cancer cells. Here we show that ACLY is acetylated at lysine …