
Acetylation Stabilizes ATP-Citrate Lyase to Promote
2013年8月22日 · Conversely, the protein deacetylase sirtuin 2 (SIRT2) deacetylates and destabilizes ACLY. Substitution of 3K abolishes ACLY ubiquitylation and promotes de novo …
SIRT2‐mediated deacetylation of ACLY promotes the progression …
2024年3月1日 · Currently, acetylation of ACLY at Lys-540, Lys-546 and Lys-554 makes ACLY more stable by antagonizing ACLY ubiquitination, and ACLY-3K acetylation can also promote …
哺乳动物 SIRT6 通过 ATP 柠檬酸裂解酶 (ACLY) 依赖性组蛋白乙酰 …
在这项研究中,我们发现了 SIRT6 在控制 ACLY 和 ACLY 依赖性肿瘤抑制基因调控的核水平方面的新功能。 癌细胞中 SIRT6 的失活导致核 ACLY 蛋白的积累并增加核乙酰辅酶 A 库,进而驱 …
郑州大学Zhang, Xueying:SIRT2介导的ACLY脱乙酰化促进食管鳞 …
2024年3月1日 · sirt2抑制剂agk2可以抑制食道鳞状细胞癌的增殖和迁移,并增加acly蛋白质的乙酰化水平。 这些结果表明,SIRT2/ACLY信号轴的靶向治疗可能是食道鳞状细胞癌的潜在治疗策 …
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in ...
2024年5月10日 · Ten DEGs associated with FAO were identified by RNA-Seq data, and ACLY, which generates acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis, was found …
Multiple Roles of SIRT2 in Regulating Physiological and …
Numerous studies have shown that lipid synthesis can be affected by regulating the acetylation state of ACLY through SIRT2 and P300/calcium-binding protein (CBP)-associated factor …
SIRT3 differentially regulates lysine benzoylation from SIRT2 in ...
2024年11月15日 · Functional investigations demonstrated SIRT3’s regulation of benzoylated protein peptidyl-prolyl cis -trans isomerase F (PPIF), where K73bz and K197bz markedly …
SIRT2-mediated deacetylation of ACLY promotes the progression …
The SIRT2 inhibitor AGK2 significantly increased the acetylation level of ACLY protein and inhibited the proliferation and migration of ESCC cells, while overexpression of ACLY partially …
<br>SIRT2介导的ACLY去乙酰化促进食管鳞状细胞癌的进 …
2024年3月1日 · SIRT2抑制剂AGK2显着增加ACLY蛋白的乙酰化水平并抑制ESCC细胞的增殖和迁移,而ACLY的过表达部分逆转了AGK2对ESCC细胞的抑制作用。 总的来说,这些结果表明 …
Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid …
ATP-citrate lyase (ACLY) is upregulated or activated in several types of cancer, and inhibition of ACLY arrests proliferation of cancer cells. Here we show that ACLY is acetylated at lysine …