In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs will be discussed. Meanwhile, the potential therapeutic strategies of …

2023年10月1日 · Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels.

2020年4月1日 · Here we will review the aging-related signaling pathways in which SIRT1 participates to regulate cellular senescence, metabolic disorders, autophagy, DNA damage and mitochondrial dysfunction, all of which are hallmarks of aging.

The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT family members have been identified in mammals, from SIRT1, the best studied for its role in vascular aging, to SIRT7.

Aging is a degenerative process associated with cumulative damage, which leads to cellular dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also known as sirtuin 1 (SIRT1), has been reported to be involved in …

2020年9月28日 · Our study reveals a mechanism in the regulation of the protein homeostasis of SIRT1 and suggests a potential strategy to stabilize SIRT1 to promote productive ageing. Sirtuins are an evolutionarily...

2021年5月28日 · Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD + -dependent SIRT6 deacylase regulates aging and metabolism through mechanisms that largely...

One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, nowadays they are known to occur in bacteria and eukaryotes (including mammals).

2016年1月19日 · A new study published in Cell Research reports a novel role for the aging-associated SIRT6 deacetylase in the control of oxidative homeostasis in human mesenchymal stem cells.

SIRT proteins, especially SIRT1, demonstrate protective roles against vascular aging. Here we will review multiple functions of SIRT proteins during vascular aging and the clinical capacity of SIRT modulators to treat cardiovascular diseases.