2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous...

2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified.

2018年10月14日 · SIRT1 protein, a member of Silent Information Regulator 2 (Sir2) protein family, have gained considerable attention as epigenetic regulators for a great area in the human physiology. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, cardiovascular diseases, cancer and neurodegeneration.

High glucose treatment significantly reduces the expression of SIRT1 protein in mouse microvascular ECs. However, overexpression of SIRT1 or metformin can attenuate the decreased expression of SIRT1 induced by high glucose, thus regulating downstream targets FOXO1 and p53/p21, and protecting ECs from high glucose-induced premature aging 151 .

2018年10月15日 · Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, cardiovascular diseases, cancer and neurodegeneration. Here, we provide an overview of the association of the increasing level of SIRT1 protein for regulating some disease related conditions such as obesity, cardiovascular diseases and neurodegeneration.

2024年1月1日 · Sterol regulatory element-binding protein (SREBP) is a substrate of SIRT1 that has attracted significant interest due to its role in multiple cellular processes including cell cycle regulation, DNA damage repair, and metabolic functions.

2017年10月1日 · SIRTs present an interesting and attractive therapeutic target in the prevention of atherosclerotic cardiovascular disease. The wide-ranging anti-atherosclerotic effects of SIRT activation afford an opportunity simultaneously to influence multiple components of the development of atherosclerotic cardiovascular disease with a single drug target.

2023年7月1日 · Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing an important part in the pathogenesis and treatment of various disorders. They have ubiquitously expressed protein deacetylases. They are implicated in several cellular activities like DNA repair, cellular metabolism, mitochondrial function, and inflammation.

SIRT1 is expressed at high levels in Th17 cells and plays an essential role in Th17 cell formation. SIRT1 binds to and deacetylates the transcription factor retinoid acid receptor-related orphan receptor gamma (RORγt), promoting the differentiation of Th17 cells by activating IL-17 and repressing the IL-2 promoter ( 82 ).

2018年9月14日 · SIRT1 has a role in cholesterol homeostasis as a positive regulator of the cholesterol-sensing proteins, liver X receptors. 197 SIRT1 knockout results in reduced liver X receptor expression and reduced high-density lipoprotein and TG lipid levels, implying a protective role of SIRT1 in increasing the levels of beneficial high-density ...