The sirtuin family in health and disease | Signal Transduction and ...
2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …
The sirtuin family in health and disease - PubMed
2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …
High Levels of SIRT1 Expression as a Protective Mechanism …
2018年10月14日 · SIRT1 protein, a member of Silent Information Regulator 2 (Sir2) protein family, have gained considerable attention as epigenetic regulators for a great area in the …
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases
High glucose treatment significantly reduces the expression of SIRT1 protein in mouse microvascular ECs. However, overexpression of SIRT1 or metformin can attenuate the …
High Levels of SIRT1 Expression as a Protective Mechanism
2018年10月15日 · Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, cardiovascular diseases, cancer and neurodegeneration. Here, we …
SIRT1/SREBPs-mediated regulation of lipid metabolism
2024年1月1日 · Sterol regulatory element-binding protein (SREBP) is a substrate of SIRT1 that has attracted significant interest due to its role in multiple cellular processes including cell …
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in ...
2017年10月1日 · SIRTs present an interesting and attractive therapeutic target in the prevention of atherosclerotic cardiovascular disease. The wide-ranging anti-atherosclerotic effects of …
A pharmacological review on SIRT 1 and SIRT 2 proteins, …
2023年7月1日 · Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing an important part in the pathogenesis and treatment of various disorders. They have …
SIRT1: A Potential Therapeutic Target in Autoimmune Diseases
SIRT1 is expressed at high levels in Th17 cells and plays an essential role in Th17 cell formation. SIRT1 binds to and deacetylates the transcription factor retinoid acid receptor-related orphan …
Sirtuins and NAD+ in the Development and Treatment of …
2018年9月14日 · SIRT1 has a role in cholesterol homeostasis as a positive regulator of the cholesterol-sensing proteins, liver X receptors. 197 SIRT1 knockout results in reduced liver X …