Here, we show that SIRT2 is a direct target gene of Wnt/β-catenin signaling in CRC cells. Inhibition or knockdown of Wnt/β-catenin increased SIRT2 promoter activity and mRNA and protein expression, whereas activation of Wnt/β-catenin decreased SIRT2 promoter activity and expression. β-Catenin was recruited to the promoter of SIRT2 and ...

2021年4月1日 · Wnt/β-catenin inhibition increases mitochondrial oxidative phosphorylation (OXPHOS) and CRC cell differentiation. Inhibition of SIRT2 decreases, while overexpression of SIRT2 increases, OXPHOS activity and differentiation in CRC cells. Inhibition of SIRT2 attenuates the differentiation induced by Wnt/β-catenin inhibition.

Increased DNA-binding to the Wnt target promoters in the absence of SIRT2 matches the increased expression of Wnt target genes. Taken together, the data suggest that SIRT2 acts as a repressor of transcription of Wnt target pro-survival genes.

2018年12月17日 · SIRT1, a protein deacetylase, known to be protective in inhibiting oxidative stress and inflammation within the vessel wall, has been shown as a possible key player in modulating the cell-fate determining canonical Wnt signaling pathways.

2017年9月7日 · SIRT7 knockdown significantly enhanced osteoblast-specific gene expression, alkaline phosphatase activity, and mineral deposition in vitro. Additionally, SIRT7 knockdown upregulated β -catenin....

2024年10月7日 · Nuclear β-catenin acts as a transcriptional co-activator, targeting genes involved in cell proliferation and invasion. 1α,25-Dihydroxyvitamin D 3 (1,25(OH) 2 D 3 or calcitriol), the active form of vitamin D, antagonizes Wnt/β-catenin …

2016年4月13日 · 同时，该项研究首次揭示了SIRT6可以从表观遗传学的层面调控造血干细胞发育和衰老过程中的重要通路（Wnt信号通路），这对于深入理解SIRT6对成体干细胞稳态维持和衰老的调控及探索干细胞衰老相关疾病的干预具有重要的意义，为干细胞衰老和相关疾病的研究和 ...

2022年3月27日 · Sirtuin-1 (SIRT1) has anti-inflammatory and antioxidant effects and has been reported to be involved in spinal cord injury (SCI). Wnt/ -catenin signal has been shown to play a critical role in the pathogenesis of chronic diseases, and it participated in the recovery of nerve function after SCI.

2022年1月3日 · sFRPs, WIF, glypicans, Tiki, and Notum are well-known regulators of Wnt/β-catenin signalling that target Wnt proteins to affect signal transduction. sFRPs have a Netrin-related motif in the C...

sirt蛋白在细胞抗逆性、能量代谢、细胞凋亡和衰老过程中具有重要作用。 sirt家族成员在组织和细胞上具有不同的定位。sirt1和sirt2主要在细胞核和细胞质中表达；sirt3、sirt4、sirt5则主要定位于线粒体；sirt6、sirt7则位于细胞核和细胞核仁内。