Bile Acid: An Elixir of Youth? | ALZFORUM
2025年1月8日 · Through metabolomic identification and subsequent investigation, they finally found the molecular analogue of CR, lithocholic acid, and verified the effect of LCA on delaying aging and extending life in worms, flies, and mice. In addition, further exploration found the molecular target of LCA, TULP3, which binds LCA to activate SIRT1.
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 …
Lv QK, Tao KX, Yao XY, Pang MZ, Cao BE, Liu CF, Wang F.Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's disease.
Edaravone mitigates TDP-43 mislocalization in human …
Edaravone mitigates TDP-43 mislocalization in human amyotrophic lateral sclerosis neurons with potential implication of the SIRT1-XBP1 pathway. Free Radic Biol Med. 2025 Feb 25;230:283-293. Epub 2025 Feb 25 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login ...
SIRT6 Reported to Destabilize APP | ALZFORUM
2024年12月19日 · They showed that SIRT1 competes with SIRT2, preventing APP from being deacetylated, hence decreasing the production of Aβ (Li et al., 2023). Another study reported that, like SIRT1, SIRT6 also was neuroprotective in mice, reducing tau phosphorylation, while in the brains of people who’d had AD, SIRT6 mRNA and protein levels had tanked ...
BPN14770 | ALZFORUM
BPN14770 antagonized the amnestic effect of the anti-nausea drug scopolamine, whereby two weeks’ dosing boosted hippocampal phospho-CREB and BDNF, markers of memory consolidation. A subsequent study implicated cAMP-PKA-SIRT1-Akt -Bcl-2/Bax signaling in BPN14770's anti-scopolamine effect in these mice (Zhang et al., 2018; Wang et al, 2020). In ...
Sirtuin Inhibitor Boosts Cognition, Reduces Phospho-tau
2008年11月21日 · These data suggest that loss of SIRT1 occurs at relatively late stages of AD, Calon told ARF. The full paper is currently in press in the Journal of Neuropathology and Experimental Neurology. Based on the nicotinamide data in mice, LaFerla’s group is recruiting mild to moderate AD patients for a six-month clinical trial.
A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine
Wang Y, Gao S, Zheng V, Chen L, Ma M, Shen S, Qu J, Zhang H, Gurney ME, O'Donnell JM, Xu Y.A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway.
Tan I modulates astrocyte inflammatory responses through …
Tan I modulates astrocyte inflammatory responses through enhanced NAD+-Sirt1 pathway: Insights from metabolomics studies. Int Immunopharmacol. 2025 Mar 1;151:114364. Epub 2025 Mar 1 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Tau Timing: New Findings on Disease Progression, Clearance
2010年10月1日 · Using transfected cell cultures, conditional knockout mice, and various loss of function and gain of function mutants, the authors then showed that it is the sirtuin protein SIRT1 that deacetylates tau both in vitro and in vivo. SIRT1 and tau co-immunoprecipitate, suggesting that they directly interact.
Edaravone - ALZFORUM
2022年12月15日 · Overview. Name: Edaravone Synonyms: MCI-186, Radicava®, Radicut®, MT-1186, FAB122 Therapy Type: Small Molecule Target Type: Other Condition(s): Amyotrophic Lateral Sclerosis U.S. FDA Status: Amyotrophic Lateral Sclerosis (Phase 4) Company: Mitsubishi Tanabe Pharma Approved for: Amyotrophic Lateral Sclerosis