2019年2月22日 · Activation of SIRT1 using a pharmacological agonist resveratrol or genetic SIRT1 overexpression significantly abolished Cd-induced activation of the IRE-1α/XBP-1s pathway and the NRLP3 inflammasome as well as pyroptosis, which were counteracted by co-overexpression of both SIRT1 and XBP-1s.

2024年6月22日 · We found that miR-22-3p intracellular effects result at least partially from the targeting of the mRNA encoding the deacetylase sirtuin-1 (SIRT1), a well-established pro-survival factor....

XBP1s and SIRT1 colocalize in the nucleus and physically bind to each other. Thus, SIRT1 deficiency in MEF cells upregulates the expression of XBP1s target genes, including Edem1, Ero1a, and Sec61a1, and increases resistance to cell death under ER stress. Studies have shown that XBP1u functions as a negative feedback regulator of XBP1s via ...

2020年10月1日 · SIRT1 can effectively regulate the proximal sensors of UPR, promote autophagy, and decrease cell apoptosis. SIRT1 can also inhibit the ER stress by significantly inhibiting the expression of the PDI protein and S-nitrosylation, increasing the expression of ORP150, FOXO1, HSP70, and HSP40, etc.

2024年1月1日 · Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of Xbp-1s and eIF2α

2024年6月22日 · We found that miR-22-3p intracellular effects result at least partially from the targeting of the mRNA encoding the deacetylase sirtuin-1 (SIRT1), a well-established pro-survival factor. Therefore, this novel XBP1s/miR-22/SIRT1 axis identified could play a pivotal role in the proliferation and chemotherapeutic response of leukemic cells.

2019年10月14日 · SIRT1 activation reduces apoptosis of IECs via the suppression of endoplasmic reticulum stress-mediated apoptosis-associated molecules CHOP and caspase-12. SIRT1 activation may be a potential therapeutic strategy for UC.

Collectively, our findings indicate that SIRT1 activity protects against Cd-induced pyroptosis through deacetylating XBP-1s, and thus inhibiting the IRE-1α/XBP-1s pathway in HK-2 cells. These results provide a novel mechanism for Cd-induced nephrotoxicity.

Sirtuin-1 (SIRT1) 是 ER 应激的有效抑制剂。 在这项研究中，我们检查了槲皮素 (QUR) 对 CdCl 诱导的大鼠肾毒性的保护作用是否涉及 SIRT1 和/或 ER 应激的调节。

2019年9月20日 · Recent reports have shown that Sirt1 deacetylates XBP1s and inhibits its transcriptional activity, whereas acetyltransferase p300 increases the acetylation and protein stability of XBP1s 15.