NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 …

SIRT3基因研究概况. SIRT3是哺乳动物 sirtuin蛋白家族 的成员，表现出 NAD+ 依赖性脱乙酰酶活性。人类sirtuins具有一系列分子功能，并已成为衰老，抗逆性和代谢调节中的重要蛋白质。

2024年12月25日 · SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, …

SIRT3 is a NAD +-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …

2019年7月11日 · Sirt3是线粒体中的一个重要的去乙酰化修饰酶，能够调控线粒体中许多代谢酶的活性，进而调控细胞线粒体的代谢。 经过多年的研究，发现Sirt3的活化与抗衰老、抗肿瘤...

Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism …

sirt3可通过各种通路及调节因子，对心肌纤维化、心肌肥厚、心肌凋亡等病理过程进行调节，对心力衰 竭的发生、发展产生重要影响。 本文主要综述 SIRT3 在心力衰竭各病理过程中的研究进 …

2025年2月1日 · SIRT3 regulates glucose uptake in cardiomyocytes and improves cardiac function in heart failure caused be blood pressure overload (Zeng et al., 2020). SIRT3 also has a key …

1 天前 · SIRT3 directly deacetylated PINK1 to promote mitophagy and cartilage anabolism. Specifically, PINK1 phosphorylated PKM2 at the Ser127 site, preserving its active tetrameric …

2012年5月15日 · SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are …