The sirtuin SIRT6 blocks IGF-Akt signaling and development of …
Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice developed cardiac …
Sirtuin 6 inhibition protects against glucocorticoid-induced …
2022年9月15日 · Here, we show that SIRT6, a chromatin-associated deacetylase indirectly regulates glucocorticoid-induced muscle wasting by modulating IGF/PI3K/AKT signaling. Our …
生信文献 | Sirt6通过介导PI3K/Akt信号通路促进弥漫性大B细胞淋 …
2021年6月9日 · 文章： Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling. 分子： Sirtuin 6 (Sirt6)是一种高度保守的ADP-核糖 …
Downregulation of hippocampal SIRT6 activates AKT/CRMP2 …
2020年4月7日 · Our in vitro data showed that SIRT6 negatively regulated protein kinase B (AKT) signaling by deacetylating histone 3 at Lys9 and Lys56. Knockdown of SIRT6 significantly …
Regulation of Akt Signaling by Sirtuins | Circulation Research
2014年1月17日 · Although SIRT1 deacetylates Akt to promote phosphatidylinositol (3,4,5)-triphosphate binding and activation, SIRT3 controls reactive oxygen species–mediated Akt …
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance ... - PubMed
In vivo experiments showed that overexpression of SIRT6 promoted the inhibitory effect of radiation on the growth of NSCLC xenograft tumors in nude mice. SIRT6 can promote the …
Emerging Roles of SIRT6 in Human Diseases and Its Modulators
In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, …
Downregulation of hippocampal SIRT6 activates AKT/CRMP2 ... - PubMed
Our in vitro data showed that SIRT6 negatively regulated protein kinase B (AKT) signaling by deacetylating histone 3 at Lys9 and Lys56. Knockdown of SIRT6 significantly increased AKT …
The sirtuin SIRT6 blocks IGF-Akt signaling and development of …
2012年10月21日 · Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice …
生信文献 | Sirt6通过介导PI3K/Akt信号通路促进弥漫性大B细胞淋 …
文章：Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling. 分子：Sirtuin 6 (Sirt6)是一种高度保守的ADP-核糖化酶和NAD+ …