Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice developed cardiac hypertrophy and heart failure, whereas SIRT6 transgenic mice were protected from hypertrophic stimuli, indicating that SIRT6 acts as a negative regulator of ...

2022年9月15日 · Here, we show that SIRT6, a chromatin-associated deacetylase indirectly regulates glucocorticoid-induced muscle wasting by modulating IGF/PI3K/AKT signaling. Our results show that SIRT6...

2021年6月9日 · 文章： Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling. 分子： Sirtuin 6 (Sirt6)是一种高度保守的ADP-核糖化酶和NAD+依赖的脱酰酶，参与广泛的细胞过程。 该酶涉及细胞抗应激、基因组稳定性、老化和能量稳态。 编码蛋白定位于细胞核，具有ADP-核糖体转移酶和组蛋白去乙酰化酶活性，在DNA修复、端粒染色质维持、炎症、脂质和糖代谢等方面发挥作用。 这种分子在致癌过程中具有相互 …

2020年4月7日 · Our in vitro data showed that SIRT6 negatively regulated protein kinase B (AKT) signaling by deacetylating histone 3 at Lys9 and Lys56. Knockdown of SIRT6 significantly increased AKT...

2014年1月17日 · Although SIRT1 deacetylates Akt to promote phosphatidylinositol (3,4,5)-triphosphate binding and activation, SIRT3 controls reactive oxygen species–mediated Akt activation, and SIRT6 transcriptionally represses Akt at the level of chromatin.

In vivo experiments showed that overexpression of SIRT6 promoted the inhibitory effect of radiation on the growth of NSCLC xenograft tumors in nude mice. SIRT6 can promote the radiosensitivity of NSCLC and inhibit the development of tumor by down-regulating the activity of PI3K/Akt/mTOR signaling pathway.

In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways.

Our in vitro data showed that SIRT6 negatively regulated protein kinase B (AKT) signaling by deacetylating histone 3 at Lys9 and Lys56. Knockdown of SIRT6 significantly increased AKT phosphorylation activity, while decreased collapsin response mediator protein 2 (CRMP2) phosphorylation activity.

2012年10月21日 · Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice developed cardiac...

文章：Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling. 分子：Sirtuin 6 (Sirt6)是一种高度保守的ADP-核糖化酶和NAD+依赖的脱酰酶，参与广泛的细胞过程。该酶涉及细胞抗应激、基因组稳定性、老化和能量稳态。