2020年4月6日 · Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. …

Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. Upon DNA damage, …

2024年9月27日 · 通过系统的构效关系研究和活性评价，最终获得了高降解活性的SIRT6小分子降解剂SZU-B6。该降解剂能够高效地降解肝癌细胞SK-HEP-1、Huh-7等肝癌细胞中的SIRT6蛋 …

Here we report that the histone deacetylase SIRT6 coordinates with the chro-matin remodeler CHD4 to promote chromatin relax-ation in response to DNA damage. Upon DNA dam-age, …

2022年11月3日 · In this study, we found that ACSL5 is deacetylated by cytoplasmic SIRT6 and that it mitigates hepatic steatosis in a HFD-induced NAFLD model. Mechanistically, we show …

2020年10月16日 · We show that SIRT6 associates with nucleosomes through two asymmetric binding sites using multiple contact points, including an intrinsically disordered C-terminus that …

2021年7月17日 · Recently an interaction between SIRT6 and a subunit of NuRD, chromodomain helicase DNA-binding protein 4 (CHD4), has been shown in response to DNA damage, …

2020年1月23日 · Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. …

sirt6可与chd4 相互作用，sirt6将chd4 募集 至DSBs 位点位点，SIRT6的C 末端域与CHD4 结 合，同时促进H3K9 脱乙酰基作用，这两点共同调

2022年12月1日 · In this study, we found that SIRT6 overexpression increased p-ATM via CHD4 during VSMC calcification. Collectively, SIRT6 deficiency in VSMCs leads to aggravation of …