
SIRT6 coordinates with CHD4 to promote chromatin relaxation …
2020年4月6日 · Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. …
SIRT6 coordinates with CHD4 to promote chromatin relaxation …
Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. Upon DNA damage, …
医学部朱卫国教授团队在表观遗传药物领域新型沉默信息调节因子SIRT6 …
2024年9月27日 · 通过系统的构效关系研究和活性评价,最终获得了高降解活性的SIRT6小分子降解剂SZU-B6。该降解剂能够高效地降解肝癌细胞SK-HEP-1、Huh-7等肝癌细胞中的SIRT6蛋 …
Here we report that the histone deacetylase SIRT6 coordinates with the chro-matin remodeler CHD4 to promote chromatin relax-ation in response to DNA damage. Upon DNA dam-age, …
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes
2022年11月3日 · In this study, we found that ACSL5 is deacetylated by cytoplasmic SIRT6 and that it mitigates hepatic steatosis in a HFD-induced NAFLD model. Mechanistically, we show …
Multivalent interactions drive nucleosome binding and …
2020年10月16日 · We show that SIRT6 associates with nucleosomes through two asymmetric binding sites using multiple contact points, including an intrinsically disordered C-terminus that …
Sirtuin 6: linking longevity with genome and epigenome stability
2021年7月17日 · Recently an interaction between SIRT6 and a subunit of NuRD, chromodomain helicase DNA-binding protein 4 (CHD4), has been shown in response to DNA damage, …
SIRT6 coordinates with CHD4 to promote chromatin
2020年1月23日 · Here we report that the histone deacetylase SIRT6 coordinates with the chromatin remodeler CHD4 to promote chromatin relaxation in response to DNA damage. …
sirt6可与chd4 相互作用,sirt6将chd4 募集 至DSBs 位点位点,SIRT6的C 末端域与CHD4 结 合,同时促进H3K9 脱乙酰基作用,这两点共同调
Deletion of SIRT6 in vascular smooth muscle cells facilitates …
2022年12月1日 · In this study, we found that SIRT6 overexpression increased p-ATM via CHD4 during VSMC calcification. Collectively, SIRT6 deficiency in VSMCs leads to aggravation of …
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