2017年7月18日 · Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O 2) consumption, obesity, decreased core body temperature, and cold sensitivity ...

4 天之前 · Our data indicate that myeloid-specific SIRT6 deficiency promoted MAOA- and SLC6A2-dependent NE degradation and impaired the thermogenesis of BAT and beige fat, suggesting that SIRT6 is essential for maintaining the function of thermogenic fat. SIRT6 knockout (KO) in myeloid cells led to obesity and insulin resistance in 20-week-old Sirt6 LysM ...

2021年6月1日 · Khan et al. show that SIRT6, a nuclear sirtuin, regulates the transcription of fatty acid transporter genes in the heart through the PPARγ transcription factor in a deacetylase-independent manner. Notably, deficiency of SIRT6 causes increased fatty acid uptake and lipid accumulation in the heart.

2019年5月21日 · Sirt6 transgenic mice show reduced fat mass, lower LDL cholesterol and triglyceride levels, and improved glucose tolerance, and these effects are mediated by suppression of PPARγ target genes...

2023年8月15日 · Results: We found that Sirt6 was downregulated in hypothalamic microglia in mice given a high-fat diet (HFD). Additionally, knockout of microglia Sirt6 exacerbated high-fat diet-induced hypothalamic microglial activation and inflammation.

In our study, we found that at the same calorie intake, a high-fat diet dramatically increased the lifespan of SIRT6 knockout mice to 26 weeks (males) and 37 weeks (females), reversed multi-organ atrophy, and reduced body weight, hypoglycemia, and premature aging.

2025年2月19日 · Additionally, SIRT6 overexpression prevents against high-fat diet (HFD)–induced obesity and related pathological damages , while depletion of SIRT6 in brown adipocytes inhibits thermogenesis and leads to obesity . These findings suggest that SIRT6 has protective functions in lipid metabolism.

3 天之前 · Sirt6 has the ability to inhibit IRS1 phosphorylation, which stops cardiomyocytes from developing insulin resistance. SIRT6 promotes mitochondrial health by preventing the generation of ROS and lipid buildup. In cardiomyocytes, SIRT6 can control Foxo1 expression, which in turn controls insulin resistance.

2013年4月3日 · It emerges that the sirtuin enzyme SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated...

SIRT6 can promote fatty acid oxidation by the activation of PPARα or the suppression of miR-122. SIRT6 can also directly modulate acyl-CoA synthetase long chain family member 5 (ACSL5) activity for fatty acid oxidation.