Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat
2017年7月18日 · Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic …
Myeloid sirtuin 6 deficiency causes obesity in mice by inducing ...
4 天之前 · Our data indicate that myeloid-specific SIRT6 deficiency promoted MAOA- and SLC6A2-dependent NE degradation and impaired the thermogenesis of BAT and beige fat, …
SIRT6 transcriptionally regulates fatty acid transport by …
2021年6月1日 · Khan et al. show that SIRT6, a nuclear sirtuin, regulates the transcription of fatty acid transporter genes in the heart through the PPARγ transcription factor in a deacetylase …
Adipose sirtuin 6 drives macrophage polarization toward M2
2019年5月21日 · Sirt6 transgenic mice show reduced fat mass, lower LDL cholesterol and triglyceride levels, and improved glucose tolerance, and these effects are mediated by …
Microglia Sirt6 modulates the transcriptional activity of NRF2 to ...
2023年8月15日 · Results: We found that Sirt6 was downregulated in hypothalamic microglia in mice given a high-fat diet (HFD). Additionally, knockout of microglia Sirt6 exacerbated high-fat …
A high-fat diet reverses metabolic disorders and premature aging …
In our study, we found that at the same calorie intake, a high-fat diet dramatically increased the lifespan of SIRT6 knockout mice to 26 weeks (males) and 37 weeks (females), reversed multi …
SIRT6 Ameliorates Cancer Cachexia–Associated Adipose Wasting …
2025年2月19日 · Additionally, SIRT6 overexpression prevents against high-fat diet (HFD)–induced obesity and related pathological damages , while depletion of SIRT6 in brown …
Role of Protein Lysine Acetylation in the Pathogenesis and …
3 天之前 · Sirt6 has the ability to inhibit IRS1 phosphorylation, which stops cardiomyocytes from developing insulin resistance. SIRT6 promotes mitochondrial health by preventing the …
Sirtuin on a high-fat diet - Nature
2013年4月3日 · It emerges that the sirtuin enzyme SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the …
Sirtuin 6—A Key Regulator of Hepatic Lipid Metabolism and Liver …
SIRT6 can promote fatty acid oxidation by the activation of PPARα or the suppression of miR-122. SIRT6 can also directly modulate acyl-CoA synthetase long chain family member 5 (ACSL5) …