2019年4月13日 · Functional studies reveal that Akt inactivation increases FoxO3a activity and augment its binding to SIRT6 promoter, leading to elevated SIRT6 expression. Knocking down SIRT6 abolished apoptotic responses and conferred resistance to the treatment of BKM120.

2013年10月11日 · Hepatic Sirt6 deficiency leads to elevated Pcsk9 gene expression and LDL-cholesterol as well. Mechanistically, we have demonstrated that Sirt6 can be recruited by forkhead transcription factor FoxO3 to the proximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expression.

2013年10月11日 · Hepatic Sirt6 deficiency leads to elevated Pcsk9 gene expression and LDL-cholesterol as well. Mechanistically, we have demonstrated that Sirt6 can be recruited by forkhead transcription factor FoxO3 to the proximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expression.

2022年9月15日 · Mechanistically, we find that SIRT6 deficiency hyperactivates IGF/PI3K/AKT signaling through c-Jun transcription factor-mediated increase in IGF2 expression. The increased activation, in turn,...

2020年7月25日 · Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles in carcinogenesis, as it has been documented to both suppressing and augmenting tumor growth.

2013年10月11日 · Hepatic Sirt6 deficiency leads to elevated Pcsk9 gene expression and LDL-cholesterol as well. Mechanistically, we have demonstrated that Sirt6 can be recruited by forkhead transcription factor FoxO3 to the proximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expression.

2025年1月27日 · We showed that SIRT6 knockdown or inhibition could promote nuclear translocation of FOXO1 by upregulation its acetylation level in M5-induced HaCat cells, indicating that SIRT6 may promote cell proliferation by reducing FOXO1 activity.

2019年4月13日 · In this study, we identified SIRT6 as a brand new transcriptional target of FoxO3a for the first time, and demonstrated Akt/FoxO3a/SIRT6 axis plays a crucial role in pro-apoptisis and colon cancer therapy by BKM120 both in vitro and in vivo. Lack of SIRT6 caused the resistance of colon cancer to BKM120 and combinational therapy.

At vascular level, the physiological functions of SIRT1 and SIRT6 in the control of the cellular redox state are mediated by deacetylation of multiple targets, including histones, transcription factors (FOXO, NF-κB, p53, and Nrf2), and enzymes involved in the vascular protection.

Hepatic deficiency of Sirt6 in mice leads to elevated cholesterol levels. On the mechanistic level, Sirt6 is recruited by forkhead box O (FoxO)3 to the Srebp2 gene promoter where Sirt6 deacetylates histone H3 at lysines 9 and 56, thereby promoting a repressive chromatin state.