Sirtuin 6 - Wikipedia
Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [5] [6] [7] In laboratory research, …
51548 - Gene ResultSIRT6 sirtuin 6 [ (human)] - National Center …
2025年2月8日 · SIRT6 suppresses colon cancer growth by inducing apoptosis and autophagy through transcriptionally down-regulating Survivin. SIRT6 prevent chronic cerebral …
SIRT6 is a key regulator of mitochondrial function in the brain
2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global …
SIRT6 sirtuin 6 [Homo sapiens (human)] - Gene - NCBI
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded …
SIRT6 Widely Regulates Aging, Immunity, and Cancer
2022年4月5日 · During the transformation from early inflammation to late inflammation, SIRT6 deacetylates H3K9ac and H3K56ac on several glycolysis gene promoters, inhibits HIF-1α …
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break …
Sirt6 is one such gene that not only regulates DNA repair, but also maintains epigenomic stability and promotes longevity. Specifically, SIRT6 promotes base excision repair (Mostoslavsky et …
Structure and Biochemical Functions of SIRT6 - ScienceDirect
2011年4月22日 · SIRT6 is a member of the evolutionarily conserved sirtuin family of NAD+-dependent protein deacetylases and functions in genomic stability and transcriptional control …
Sirtuin 6: linking longevity with genome and epigenome stability
2021年7月17日 · Sirtuin 6 (SIRT6) extends mammalian lifespan and promotes healthspan. SIRT6 maintains genomic stability through improved efficiency of DNA repair. SIRT6 maintains …
Sirtuin 6: a review of biological effects and potential therapeutic ...
SIRT6, an enzyme highly expressed in skeletal muscles, brain, heart, liver, and thymus, affects transcriptional regulation in a tissue-specific manner. This enzyme has a two-domain structure …
SIRT6, a protein with many faces | Biogerontology - Springer
2013年11月10日 · The human SIRT6 gene is localized to chromosome 19p13.3 and consists of 8 exons ranging in size from 60 bp (Mahlknecht et al. 2006) to 838 bp (Mahlknecht et al. 2006). …