Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [5] [6] [7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [5]

2025年2月8日 · SIRT6 suppresses colon cancer growth by inducing apoptosis and autophagy through transcriptionally down-regulating Survivin. SIRT6 prevent chronic cerebral hypoperfusion induced cognitive impairment by remodeling mitochondrial dynamics in a STAT5-PGAM5-Drp1 dependent manner.

2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global downregulation of...

This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of ...

2022年4月5日 · During the transformation from early inflammation to late inflammation, SIRT6 deacetylates H3K9ac and H3K56ac on several glycolysis gene promoters, inhibits HIF-1α transcriptional activity, and reduces glycolysis activity to promote M2 polarization of macrophages .

Sirt6 is one such gene that not only regulates DNA repair, but also maintains epigenomic stability and promotes longevity. Specifically, SIRT6 promotes base excision repair (Mostoslavsky et al., 2006) and both the homologous recombination (HR) and the non-homologous end joining (NHEJ) pathways of DSB repair (Mao et al., 2011; Toiber et al., 2013).

2011年4月22日 · SIRT6 is a member of the evolutionarily conserved sirtuin family of NAD+-dependent protein deacetylases and functions in genomic stability and transcriptional control of glucose metabolism. Early reports suggested that SIRT6 performs ADP-ribosylation, whereas more recent studies have suggested that SIRT6 functions mainly as a histone deacetylase.

2021年7月17日 · Sirtuin 6 (SIRT6) extends mammalian lifespan and promotes healthspan. SIRT6 maintains genomic stability through improved efficiency of DNA repair. SIRT6 maintains heterochromatin and silences repetitive genetic elements. Regulation of SIRT6 is a potential strategy for rejuvenation.

SIRT6, an enzyme highly expressed in skeletal muscles, brain, heart, liver, and thymus, affects transcriptional regulation in a tissue-specific manner. This enzyme has a two-domain structure that consists of a large Rossmann fold and a smaller and structurally more varied sequence containing a Zn (2+)-binding motif.

2013年11月10日 · The human SIRT6 gene is localized to chromosome 19p13.3 and consists of 8 exons ranging in size from 60 bp (Mahlknecht et al. 2006) to 838 bp (Mahlknecht et al. 2006). Its open reading frame encodes a 355-aa protein with a predicted molecular weight of 39.1 kDa and an isoelectric point of 9.12 (Mahlknecht et al. 2006 ).