2009年1月9日 · SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters. In SIRT6-deficient cells, hyperacetylation of H3K9 at these target promoters is associated with increased RELA promoter occupancy and enhanced NF-kappaB-dependent modulation of gene expression, apoptosis, and cellular ...

SIRT6（Sirtuin 6）是一种NAD+依赖的去乙酰化酶，其被证实可对组蛋白H3K9、H3K18和H3K56进行去乙酰化修饰，进而在细胞代谢、DNA损伤修复、炎症反应以及肿瘤发生发展等多个生理进程中发挥重要作用。

2008年3月12日 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and...

2010年1月22日 · Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes. Specifically, SIRT6 appears to function as a corepressor of the transcription factor Hif1alpha, a critical regulator of nutrient stress responses.

2008年3月27日 · Here we show that the human SIRT6 protein is an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence.

We propose that SIRT6 attenuates NF-kappaB signaling via H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling may contribute to premature and normal aging. NAD 依赖性脱乙酰酶的 Sirtuin (SIRT) 家族成员可促进多种生物体的长寿。 哺乳动物 SIRT6 的缺乏导致小鼠寿命缩短和衰老样表型，但潜在的分子机制尚不清楚。 在这里，我们展示了 SIRT6 在染色质上的功能，以减弱 NF-kappaB 信号。

2013年4月3日 · To discover possible novel activity of SIRT6, we synthesized H3K9 peptides with different acyl groups (acetyl, malonyl, succinyl, butyryl, myristoyl and palmitoyl) and assayed these peptides...

2009年1月9日 · SIRT6 interacts with the NF-κB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-κB target gene promoters. In SIRT6-deficient cells, hyperacetylation of H3K9 at these target promoters is associated with increased RELA promoter occupancy and enhanced NF-κB-dependent modulation of gene expression, apoptosis, and cellular senescence.

Early studies identified glycolytic genes as direct targets of SIRT6, in which SIRT6 deacetylated H3K9, repressing these genes and influencing glucose metabolism. At the promoters of key glycolytic genes, SIRT6 deacetylates histone H3K9, thereby repressing the expression of key enzymes and glycolytic genes, including GLUT1, PDK1, and LDHA.

5 天之前 · Myeloid-specific SIRT6 deficiency promoted H3K9 acetylation in the promoter regions and the expression of genes encoding the norepinephrine-degrading enzyme MAOA and the norepinephrine transporter SLC6A2 in macrophages in BAT, leading to norepinephrine degradation and obesity. Our findings indicate that SIRT6 in macrophages is essential for ...