SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB ... - PubMed
2009年1月9日 · SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters. In SIRT6-deficient cells, …
SIRT6 inhibits inflammatory response through regulation of …
The present study showed that TNF-α significantly reduced the expression of SIRT6 protein and mRNA in a concentration- and time-dependent manner and increased the expression of …
Sirt6 mediates antioxidative functions by increasing Nrf2 abundance
2023年1月1日 · Sirt6, a member of the mammalian homolog family of yeast Sir2 NAD + -dependent histone deacetylases, regulates multiple biological processes. Sirt6 exerts …
Structure and Biochemical Functions of SIRT6 - ScienceDirect
2011年4月22日 · SIRT6 is a member of the evolutionarily conserved sirtuin family of NAD +-dependent protein deacetylases and functions in genomic stability and transcriptional control …
SIRT6: Novel Mechanisms and Links to Aging and Disease
SIRT6, a member of the Sirtuin family of NAD +-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …
SIRT6 inhibits inflammatory response through regulation of NRF2 …
2021年10月1日 · We found that SIRT6 promoted NRF2 phosphorylation. SIRT6 overexpression increased mRNA levels of NRF2 target genes and SIRT6 knockdown decreased mRNA levels …
Sirt6 attenuates chondrocyte senescence and osteoarthritis
2022年12月10日 · Here we show that Sirt6 deficiency exaggerates chondrocyte senescence and osteoarthritis progression, whereas intra-articular injection of adenovirus-Sirt6 markedly …
SIRT6 is a key regulator of mitochondrial function in the brain
2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global …
SIRT6 safeguards human mesenchymal stem cells from oxidative …
2016年1月15日 · Our study uncovers a novel function of SIRT6 in maintaining hMSC homeostasis by serving as a NRF2 coactivator, which represents a new layer of regulation of oxidative …
Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation
2023年3月17日 · The sirtuins are a family of NAD-dependent HDAC enzymes, and one member, sirtuin 6 (Sirt6), influences DNA repair, transcription, and aging. Here, we demonstrate that …