SIRT6 interacted with NRF2. In vivo, the levels of TNF-α and IL-1β were increased in the serum of hyperlipidemia mice. Hyperlipidemia-induced production of MCP-1, IL-6 and IL-1β was significantly augmented in the endothelium specific SIRT6 knockout mice. In contrast, the expression of NRF2 and its target genes was reduced.

2016年1月15日 · Our study provides first evidence that SIRT6 is a key gatekeeper for human adult stem cell homeostasis, highlighting that SIRT6-NRF2 pathway may be a novel target for preventing...

2023年1月1日 · Sirt6, a member of the mammalian homolog family of yeast Sir2 NAD +-dependent histone deacetylases, regulates multiple biological processes. Sirt6 exerts antioxidative functions by enhancing DNA repair and DNA end resection. In our study, we found that Sirt6 expression was induced by H 2 O 2 and paraquat (PQ) in cells.

2024年8月3日 · [结论]SIRT6过表达抑制AngⅡ诱导的心肌细胞凋亡与AMPK/Nrf2/HO-1信号通路的激活有关。 Aim To investigate whether SIRT6 overexpression inhibits angiotensin Ⅱ (AngⅡ)-induced cardiomyocyte apoptosis by activating adenosine 5′-monophosphate-activated protein kinase/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 …

2023年1月1日 · Since both Sirt6 and Nrf2 have protective effects under oxidative stress, we have investigated whether specific interactions between Sirt6 and Nrf2 occur as part of the antioxidative function. In this study, we found that Sirt6 exerted antioxidative effects by …

Nrf2 与 SIRT6 结合的表征对于理解 SIRT6 对 Nrf2 相关细胞活性的调节至关重要。 酵母双杂交实验表明，Nrf2 与 SIRT6 的结合是由 Neh1 和 Neh3 结构域介导的。 根据分子动力学分析，Neh1 和 Neh3 结构域的消除降低了结合稳定性和自由能。

2023年10月15日 · We proffer substantiation that overexpression of SIRT6 protects skin fibroblasts from UVA-induced oxidative stress by activating the NRF2/HO-1 signaling cascade. Moreover, SIRT6 overexpression also reduced UVA-induced type I collagen degradation by inhibiting NF-κB signaling cascade.

2023年12月1日 · SIRT6 activates the NRF2/HO-1 signaling transduction, which promotes downstream antioxidant enzymes to clear ROS and suppress cellular senescence. Moreover, SIRT6 inhibits the NF-κB signaling pathway, which reduces the synthesis of MMP-1 and MMP-3, ultimately preventing the degradation of type I collagen.

sirt1、sirt3、sirt6通过对ampk的促进与激活，抑制细胞氧化应激，减少ros和脂质过氧化； sirt1、sirt2、sirt6可以激活nrf2，调节抗氧化基因表达，从而对抗氧化应激损伤； sirt3激活foxo3基因表达，sirt1通过控制foxo1和foxo3a的转录活性缓解氧化应激；sirt3激活foxo3基因表达 ...

2021年7月4日 · 敲低 sirt6 显著增强 tnf α诱导的 mcp-1 、 il-6 和 il-1β 的表达。此外，敲低 sirt6 降低了 tnf α诱导的核因子红细胞 2 相关因子 2 （nrf2） 核蛋白表达，而敲低 nrf2 显着增强了 tnf α诱导的 mcp-1 、 il-6 和 il-1β 的表达。