2020年7月25日 · PI3K signaling along with phosphorylation of its downstream targets was reduced upon Sirt6 downregulation. Xenograft models subjected to either OSS_128167 …

2021年6月9日 · 文章： Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling. 分子： Sirtuin 6 (Sirt6)是一种高度保守的ADP-核糖 …

In vivo experiments showed that overexpression of SIRT6 promoted the inhibitory effect of radiation on the growth of NSCLC xenograft tumors in nude mice. SIRT6 can promote the …

SIRT6-sensitive cancer cells bear mutations that activate phosphatidylinositol-3-kinase (PI3K) signaling, and overexpression of SIRT6 reduces growth, progression, and grade of breast …

2017年2月21日 · SIRT6 overexpression suppresses PI3K signaling at the transcriptional level and antagonizes tumor sphere formation independent of its histone deacetylase activity. Our data …

2022年9月15日 · Here, we show that SIRT6, a chromatin-associated deacetylase indirectly regulates glucocorticoid-induced muscle wasting by modulating IGF/PI3K/AKT signaling. Our …

结论 去乙酰化酶SIRT6 能够通过下调PI3K-AKT 通路从而抑制肾癌细胞的增殖、迁 移，可能成为药物治疗的潜在新靶点。 关键词 SIRT6;肾癌细胞;ACHN;786-O;OSS_128167;迁移; 增殖 中图 …

2019年11月13日 · OSS_128167, a novel targeted inhibitor of Sirt6, exerted excellent anti-lymphoma effects via activating PI3K/Akt/mTOR signaling. In addition, blockade of Sirt6 …

2021年5月25日 · SIRT6 can promote the radiosensitivity of NSCLC and inhibit the development of tumor by down-regulating the activity of PI3K/Akt/mTOR signaling pathway.

OSS_128167 是一种新型的 Sirt6 靶向抑制剂，通过激活 PI3K/Akt/mTOR 信号传导发挥出色的抗淋巴瘤作用。 此外，Sirt6 表达的阻断增强了 DLBCL 细胞对化疗药物的敏感性。