SIRT6 is a key regulator of mitochondrial function in the brain
2023年1月18日 · Our results demonstrate that the lack of SIRT6 leads to decreased mitochondrial gene expression and metabolomic changes of TCA cycle byproducts, including increased …
Restoration of energy homeostasis by SIRT6 extends healthy …
2021年5月28日 · Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in …
SIRT6 is a histone H3 lysine 9 deacetylase that modulates ... - Nature
2008年3月12日 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates …
Sub-cellular localization, expression and functions of Sirt6 during …
Sirtuin 6 (Sirt6), a mammalian Sir2 (silent information regulator-2) ortholog, is an NAD +-dependent histone deacetylase that modulates chromatin structure and genomic stability. Sirt6 …
Circ-Sirt6 promotes the stability and expression of m6A modified Sirt6 …
2025年2月28日 · Mechanistically, circ-Sirt6 specifically binds to IGF2BP2 and promotes the stability and expression of Sirt6 mRNA by enhancing its m 6 A modification. Our findings …
Sirt6 regulates the proliferation of neural precursor cells and ...
2024年2月16日 · Combined with the RNA-seq results, the SIRT6 protein may regulate the Notch pathway to influence stem cell proliferation. Our study sheds new light on Sirt6’s crucial role in …
SIRT6 transcriptionally regulates fatty acid transport by …
2021年6月1日 · Khan et al. show that SIRT6, a nuclear sirtuin, regulates the transcription of fatty acid transporter genes in the heart through the PPARγ transcription factor in a deacetylase …
The Histone Deacetylase SIRT6 Restrains Transcription Elongation …
2019年8月22日 · Here, we demonstrate that the histone deacetylase SIRT6 binds to Pol II and prevents the release of the negative elongation factor (NELF), thus stabilizing Pol II promoter …
The Histone Deacetylase SIRT6 Restrains Transcription ... - Cell Press
Our results identified SIRT6 as a Pol II promoter-proximal pausing-dedicated histone deacetylase. Environmental adaptation is a fundamental trait of all living organisms. Individual cells rely on …
SIRT6 mono-ADP ribosylates KDM2A to locally increase …
Here we show that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA repair by transiently repressing transcription. Specifically, SIRT6 mono-ADP ribosylates the lysine …