
SIRT6 is a key regulator of mitochondrial function in the brain
2023年1月18日 · Our results demonstrate that the lack of SIRT6 leads to decreased mitochondrial gene expression and metabolomic changes of TCA cycle byproducts, including increased ROS production, reduced...
Restoration of energy homeostasis by SIRT6 extends healthy …
2021年5月28日 · Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in vivo multi-omics analyses...
SIRT6 is a histone H3 lysine 9 deacetylase that modulates ... - Nature
2008年3月12日 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and...
Sub-cellular localization, expression and functions of Sirt6 during …
Sirtuin 6 (Sirt6), a mammalian Sir2 (silent information regulator-2) ortholog, is an NAD +-dependent histone deacetylase that modulates chromatin structure and genomic stability. Sirt6 knockout cells demonstrate genomic instability, and a deficiency of Sirt6 in mice leads to an aging phenotype early in life.
Circ-Sirt6 promotes the stability and expression of m6A modified Sirt6 …
2025年2月28日 · Mechanistically, circ-Sirt6 specifically binds to IGF2BP2 and promotes the stability and expression of Sirt6 mRNA by enhancing its m 6 A modification. Our findings highlight the importance of circ-Sirt6-mediated m 6 A in VSMC phenotype switching. Circ-Sirt6 may be a novel biological target for CAD.
Sirt6 regulates the proliferation of neural precursor cells and ...
2024年2月16日 · Combined with the RNA-seq results, the SIRT6 protein may regulate the Notch pathway to influence stem cell proliferation. Our study sheds new light on Sirt6’s crucial role in brain development. Results
SIRT6 transcriptionally regulates fatty acid transport by …
2021年6月1日 · Khan et al. show that SIRT6, a nuclear sirtuin, regulates the transcription of fatty acid transporter genes in the heart through the PPARγ transcription factor in a deacetylase-independent manner. Notably, deficiency of SIRT6 causes increased fatty acid uptake and lipid accumulation in the heart.
The Histone Deacetylase SIRT6 Restrains Transcription Elongation …
2019年8月22日 · Here, we demonstrate that the histone deacetylase SIRT6 binds to Pol II and prevents the release of the negative elongation factor (NELF), thus stabilizing Pol II promoter-proximal pausing.
The Histone Deacetylase SIRT6 Restrains Transcription ... - Cell Press
Our results identified SIRT6 as a Pol II promoter-proximal pausing-dedicated histone deacetylase. Environmental adaptation is a fundamental trait of all living organisms. Individual cells rely on molecular sensors altering their activities in response to …
SIRT6 mono-ADP ribosylates KDM2A to locally increase …
Here we show that the SIRT6 protein enhances non-homologous end joining (NHEJ) DNA repair by transiently repressing transcription. Specifically, SIRT6 mono-ADP ribosylates the lysine demethylase JHDM1A/KDM2A leading to rapid displacement of KDM2A from chromatin, resulting in increased H3K36me2 levels.