Identification of a cellularly active SIRT6 allosteric activator - Nature
2018年10月29日 · SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone H3 Nε -acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor …
Discovery of a potent and highly selective inhibitor of SIRT6 …
2024年3月1日 · Here, we developed a novel SIRT6 allosteric inhibitor, compound 11e, with maximal inhibitory potency and an IC 50 value of 0.98 ± 0.13 μmol/L. Moreover, compound …
Targeting a cryptic allosteric site of SIRT6 with small-molecule ...
2022年2月1日 · SIRT6 belongs to the conserved NAD +-dependent deacetylase superfamily and mediates multiple biological and pathological processes. Targeting SIRT6 by allosteric …
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes
2022年11月3日 · Histone deacetylase Sirtuin 6 (SIRT6) regulates NAFLD by regulating metabolism-related gene expression, but an extrachromosomal role for SIRT6 in NAFLD …
Structural basis for the activation and inhibition of Sirtuin 6 by ...
2019年12月16日 · Mammalian Sirtuin 6 (Sirt6) is an NAD + -dependent protein deacylase regulating metabolism and chromatin homeostasis. Sirt6 activation protects against metabolic …
Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives …
2020年8月15日 · SIRT6 is a deacetylase of histone H3 and inhibitors of SIRT6 have been thought as potential agents for treatment of diabetes. Herein we report the discovery of a series of new …
Natural polyphenols as sirtuin 6 modulators | Scientific Reports
2018年3月7日 · Because SIRT6 has been implicated in longevity, metabolism, DNA-repair, and inflammatory response reduction, it is an interesting target in inflammatory and metabolic …
SIRT6 transcriptionally regulates global protein synthesis …
Here, we report that SIRT6, a nuclear-localized histone deacetylase represses global protein synthesis by transcriptionally regulating mTOR signalling via the transcription factor Sp1, …
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver ...
2016年1月12日 · To experimentally measure affinity of miR-122 and SIRT6 association, surface plasmon resonance (SPR) assay was used to examine the binding parameters of miR-122 …
SIRT6 is a DNA double-strand break sensor - PMC - PubMed …
SIRT6 relocates to sites of damage independently of signaling and known sensors. It activates downstream signaling for DSB repair by triggering ATM recruitment, H2AX phosphorylation …