2024年12月5日 · MEMA enhanced hepatic SIRT6 and downregulated p-AKT/mTOR signaling, that subsequently reduced expressions of the lipid synthesis biomarkers (SREBP1c, SCD), while elevating the lipid oxidation markers (PPAR-α, CPT1).

sirt1、sirt3、sirt6通过对ampk的促进与激活，抑制细胞氧化应激，减少ros和脂质过氧化； sirt1、sirt2、sirt6可以激活nrf2，调节抗氧化基因表达，从而对抗氧化应激损伤； sirt3激活foxo3基因表达，sirt1通过控制foxo1和foxo3a的转录活性缓解氧化应激；sirt3激活foxo3基因表达 ...

Here, we report that SIRT6, a nuclear-localized histone deacetylase represses global protein synthesis by transcriptionally regulating mTOR signalling via the transcription factor Sp1, independent of its deacetylase activity. Our results suggest that SIRT6 deficiency increases protein synthesis in mice.

2024年10月24日 · MEMA enhanced hepatic SIRT6 and downregulated p-AKT/mTOR signaling, that subsequently reduced expressions of the lipid synthesis biomarkers (SREBP1c, CPT1), while elevating the lipid oxidation markers (PPAR-α, SCD).

2021年12月18日 · Recombinant SIRT6 alleviated the decrease in AMPKα and increase in mTORC1 (complex of mTOR, Raptor, and Rheb) caused by overnutrition. SIRT6 siRNA reversed the glucolipid metabolic disorders...

重组 SIRT6 减轻了由营养过剩引起的 AMPKα 减少和 mTORC1（mTOR、Raptor 和 Rheb 的复合物）的增加。 SIRT6 siRNA 可逆转由 AMPK 激动剂和 mTOR 抑制剂引起的糖脂代谢紊乱，但不能逆转由 LXR 激动剂引起的糖脂代谢紊乱。

In vivo experiments showed that overexpression of SIRT6 promoted the inhibitory effect of radiation on the growth of NSCLC xenograft tumors in nude mice. SIRT6 can promote the radiosensitivity of NSCLC and inhibit the development of tumor by down-regulating the activity of PI3K/Akt/mTOR signaling pathway.

2021年5月25日 · SIRT6 can promote the radiosensitivity of NSCLC and inhibit the development of tumor by down-regulating the activity of PI3K/Akt/mTOR signaling pathway.

We provide evidence that SIRT6 is the FoxO1 deacetylase suppressed by mTORC2 and show an endogenous interaction between SIRT6 and mTORC2 in both mouse and human cells. Our findings suggest a new paradigm of mTORC2 function filling an important gap in our understanding of this more mysterious mTOR complex. mTORC2 控制葡萄糖和脂质代谢，但其机 …

雷帕霉素靶蛋白(mTOR)信号通路、自噬(Autophagy)以及沉默信息调节蛋白6 (Sirt6)被认为可能参与了纤维化过程的发生，但其中的机理还不明确。 我们已发表的研究表明IPF患者肺内存在mTOR信号活化以及活化的mTOR信号可通过抑制自噬形成介导肺纤维化发病。