2021年4月27日 · Here, we show that Tau hyper-acetylation at residue 174 increases its own nuclear presence and is the result of DNA damage signaling or the lack of SIRT6, both causative of neurodegeneration. Tau-K174ac is deacetylated in the nucleus by SIRT6. However, lack of SIRT6 or chronic DNA damage results in nuclear Tau-K174ac accumulation.

Sirtuin 6 (Sirt6), a mammalian Sir2 (silent information regulator-2) ortholog, is an NAD +-dependent histone deacetylase that modulates chromatin structure and genomic stability. Sirt6 knockout cells demonstrate genomic instability, and a deficiency of Sirt6 in mice leads to an aging phenotype early in life.

2024年5月29日 · Here, we show that SIRT6 has a critical role in maintaining proteostasis. It negatively regulates global translation by controlling ribosomal genes, nucleolar function and TIP5 chromatin localization. SIRT6 deletion dramatically increases nucleolar size, rRNA production and protein translation.

2014年1月1日 · Sirtuin 6 (SIRT6), a member of the mammalian sirtuin family, is a nuclear deacetylase with substrate-specific NAD + -dependent activity. SIRT6 has emerged as a critical regulator of diverse processes, including DNA repair, gene expression, telomere maintenance, and metabolism.

摘要: SIRT6作为组蛋白去乙酰化转移酶 (Histone deacetylases，HDACs) 第三家族长寿蛋白 (Sirtuins，SIRTs) 中的一员，具有多种催化酶活性，且在抗衰老、染色质调节、转录调控、糖脂代谢、DNA损伤修复等生物学过程中起着重要的作用。 近年来的证据表明，SIRT6的表达与肿瘤的发生发展密切相关，且在多种肿瘤中起着关键的调节作用，比如肝癌、肺癌、乳腺癌和生殖系统肿瘤等。 但是由于SIRT6功能的多样性，及其上下游信号通路的复杂性，SIRT6在肿瘤中可能扮演 …

2016年1月15日 · In addition, we found SIRT6 in a protein complex with both nuclear factor erythroid 2-related factor 2 (NRF2) and RNA polymerase II, which was required for the transactivation of NRF2-regulated...

2024年11月7日 · We provide evidence that SIRT6-mediated deacetylation of hnRNPA2B1 at the K113 and K173 residues plays a crucial role in facilitating its displacement from DSB sites and triggers repression of...

2020年8月7日 · Sirtuin 6 (SIRT6) is a nuclear NAD +-dependent deacetylase of histone H3 that regulates genome stability and gene expression. However, nonhistone substrates and additional catalytic activities of SIRT6, including long-chain deacylation and mono-ADP-ribosylation of other proteins, have also been reported, but many of these noncanonical roles ...

2024年2月16日 · After the generation of a cortex-specific Sirt6 conditional knockout mouse model, we investigated the specific deletion of Sirt6 in NPCs at E10.5. This study found that Sirt6 deficiency causes excessive proliferation of neural precursor cells …

The coding sequence (CDS) of Sirt6 genes from these 7 species were amplified by RT-PCR using mRNA prepared from young cells (PD < 10) of the corresponding species and sequenced to verify the correct cloning. Sirt6 CDS were then cloned into pEGFP-N1 …