2021年4月27日 · Here, we show that Tau hyper-acetylation at residue 174 increases its own nuclear presence and is the result of DNA damage signaling or the lack of SIRT6, both …

Sirtuin 6 (Sirt6), a mammalian Sir2 (silent information regulator-2) ortholog, is an NAD +-dependent histone deacetylase that modulates chromatin structure and genomic stability. Sirt6 …

2024年5月29日 · Here, we show that SIRT6 has a critical role in maintaining proteostasis. It negatively regulates global translation by controlling ribosomal genes, nucleolar function and …

2014年1月1日 · Sirtuin 6 (SIRT6), a member of the mammalian sirtuin family, is a nuclear deacetylase with substrate-specific NAD + -dependent activity. SIRT6 has emerged as a …

摘要: SIRT6作为组蛋白去乙酰化转移酶 (Histone deacetylases，HDACs) 第三家族长寿蛋白 (Sirtuins，SIRTs) 中的一员，具有多种催化酶活性，且在抗衰老、染色质调节、转录调控、糖 …

2016年1月15日 · In addition, we found SIRT6 in a protein complex with both nuclear factor erythroid 2-related factor 2 (NRF2) and RNA polymerase II, which was required for the …

2024年11月7日 · We provide evidence that SIRT6-mediated deacetylation of hnRNPA2B1 at the K113 and K173 residues plays a crucial role in facilitating its displacement from DSB sites and …

2020年8月7日 · Sirtuin 6 (SIRT6) is a nuclear NAD +-dependent deacetylase of histone H3 that regulates genome stability and gene expression. However, nonhistone substrates and …

2024年2月16日 · After the generation of a cortex-specific Sirt6 conditional knockout mouse model, we investigated the specific deletion of Sirt6 in NPCs at E10.5. This study found that Sirt6 …

The coding sequence (CDS) of Sirt6 genes from these 7 species were amplified by RT-PCR using mRNA prepared from young cells (PD < 10) of the corresponding species and sequenced to …