2008年8月21日 · We have identified common variants in SLCO1B1 that are strongly associated with an increased risk of statin-induced myopathy. Genotyping these variants may help to achieve the benefits of...

The solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encodes for a membrane-bound sodium-independent organic anion transporter protein (OATP1B1) that is involved in active cellular influx of many endogenous and xenobiotic compounds.

The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.

2024年12月25日 · SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) is a Protein Coding gene. Diseases associated with SLCO1B1 include Hyperbilirubinemia, Rotor Type and Gilbert Syndrome. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Lovastatin Pathway, Pharmacokinetics.

SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein …

2018年9月17日 · Performing SLCO1B1 testing led to an increased willingness by providers to reinitiate statins and improved patient perceptions of statin therapy. This translated into a 20 mg/dL reduction in LDL-C levels during the trial in the GIST group and a 14.9 mg/dL reduction in the usual care group that received the pharmacogenetic test results at the ...

SLCO1B1 encodes for one of the major hepatic influx transport proteins organic anion transporting polypeptide 1B1 (OATP1B1), also referred to as SLCO1B1, and previously as OATP-C, OATP2, and liver specific transporter 1 (LST-1).

Title: The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia. Non-targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function.

The SLCO1B1 gene encodes the organic anion transporter OATP1B, which plays an important role in the hepatocellular uptake of a variety of endogenous compounds and drugs. You might find these chapters and articles relevant to this topic.

The SLCO1B1 gene influences how certain medications move through the body, and primarily impacts medications used for treating high cholesterol. If you have been diagnosed with high cholesterol and your healthcare provider is considering any of the