2019年5月4日 · Background: SLE is associated with increased risk of diffuse large B-cell lymphoma (DLBCL). DLBCL is routinely classified by cell of origin (COO), with germinal centre B-cell (GCB) being more common and indicating better prognosis in the general population. We studied COO subtyping in patients with SLE diagnosed with DLBCL and their survival.

2022年4月8日 · Cell type-specific expression features predicted case-control status and stratified patients into two molecular subtypes. We integrated dense genotyping data to map cell type-specific cis-expression quantitative trait loci and to link SLE-associated variants to cell type-specific expression.

通过对SLE患者外周血中CD19+ B细胞进行单细胞测序分析，研究发现43个在ABCs中差异表达的转录因子，并在SLE小鼠的ABCs中验证，将差异表达的目标转录因子缩小为16个。

2018年5月15日 · Here we show that genetic deletion of the de novo DNA methyltransferases Dnmt3a and Dnmt3b (Dnmt3-deficient) in mouse B cells results in normal B cell development and maturation, but increased cell...

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with different degrees of disease activity and 11 match …

2020年8月3日 · Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled...

SLE has been consistently associated with an increased incidence of malignant lymphoma, especially the DLBCL subtype. Since the last WHO classification of 2008 DLBCL are now further divided, based on the cell-of-origin (COO) subtypes.

DLBCL is routinely classified by cell-of-origin (COO), with non-germinal centre B-cell (GCB) indicating poorer prognosis in the general population. We studied COO subtyping in SLE patients diagnosed with DLBCL, and overall survival. Methods: …

2022年4月8日 · 系统性红斑狼疮（SLE）是一种影响多器官系统的异质性自身免疫性疾病，在亚洲、非洲和西班牙裔女性和个体中患病率较高。 大量的常规转录组研究发现：I型干扰素信号通路增加、淋巴细胞激活失调和凋亡清除失败是SLE疾病的标志。

2021年9月14日 · Here, we report increased expression of AIM2 in human tonsil memory and germinal center (GC) B cells and in memory B cells and plasma cells from the circulation and skin lesions of lupus patients....