Interferon pathway in SLE: one key to unlocking the mystery of …
The reasons behind the IFN signature in SLE are (1) the existence of endogenous IFN inducers, (2) activation of several IFN-producing cell types, (3) production of many different IFNs, (4) a …
Emerging concepts of type I interferons in SLE pathogenesis
2022年9月12日 · IFN-Score-B is able to differentiate the interferon signature in SLE and RA, can predict progression to SLE in ANA-positive at-risk individuals and can better predict response to...
Targeting type I interferons in systemic lupus erythematous
Autoantibody formation and immune complex formation are important mediators in lupus pathogenesis, but an important role of the type I interferon (IFN) pathway has been identified …
Type I interferon in the pathogenesis of systemic lupus …
Type I IFN is implicated in SLE pathogenesis by multiple lines of evidence, including genetics, gene expression, and induction of SLE by IFN treatment. Nucleic-acid sensing pathways …
Interferons in Systemic Lupus Erythematosus - PMC
Skewing of type I interferon (IFN) production and responses is a hallmark of systemic lupus erythematosus (SLE). Genetic and environmental contributions to IFN production lead to …
Role of interferons in SLE - PubMed
In this review, we discuss the current understanding of IFNs in SLE, focusing on their regulation, the influence of genetic background, and environmental factors and therapies that are under …
Gene expression analysis delineates the potential roles of multiple ...
2019年4月23日 · A role for interferon (IFN) in systemic lupus erythematosus (SLE) pathogenesis is inferred from the prominent IFN gene signature (IGS), but the major IFN species and its …
Uncoupling interferons and the interferon signature explains …
2024年5月21日 · Systemic lupus erythematosus (SLE) displays a hallmark interferon (IFN) signature. Yet, clinical trials targeting type I IFN (IFN-I) have shown variable efficacy, and …
Role of interferons in SLE - ScienceDirect
2017年6月1日 · In this review, we discuss the current understanding of IFNs in SLE, focusing on their regulation, the influence of genetic background, and environmental factors and therapies …
Type I IFN system in the development and manifestations of SLE
Purpose of review: Type I interferon (IFN-I) is strongly implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we focus on new developments in pathways of IFN-I …
Targeting type I interferon in systemic lupus erythematosus
2016年5月26日 · Type I interferon (IFN) is an attractive therapeutic target in systemic lupus erythematosus (SLE), a notion bolstered by the positive results of a recent clinical trial...
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN …
2025年3月7日 · The skin is the most commonly affected organ of patients with lupus ().Nonlesional skin of patients at risk for lupus exhibits robust IFN secretion even with minimal …
IFN-γ, should not be ignored in SLE - PubMed
2022年8月10日 · Due to the large overlap between IFN-α and IFN-γ, SLE is mostly characterized by expression of the IFN-α gene after onset. Therefore, the role of IFN-γ in SLE may be …
Type I Interferons in Systemic Lupus Erythematosus: A Journey …
Dysregulation of type I interferons (IFNs) has been implicated in the pathogenesis of systemic lupus erythematosus (SLE) since the late 1970s. The majority of SLE patients demonstrate …
Type I interferon in the pathogenesis of systemic lupus erythematosus
2020年12月1日 · Type I IFN is implicated in SLE pathogenesis by multiple lines of evidence, including genetics and induction of SLE by IFN treatment. Nucleic-acid sensing pathways …
A focused report on IFN-1 targeted therapies for lupus …
2025年3月6日 · High levels of IFN-I (type 1 interferon) are present in most SLE patients, making this pathway an attractive target for drug development. Litifilimab downregulates IFN-I by …
Type I IFN drives unconventional IL-1β secretion in lupus monocytes
2024年10月7日 · Opsonization of red blood cells that retain mitochondria (Mito + RBCs), a feature of systemic lupus erythematosus (SLE), triggers type I interferon (IFN) production in …
Optimal Selection of IFN-α-Inducible Genes to Determine
2023年3月12日 · Elevated type I interferon signature (IFN- I) in SLE leads to dysregulation of innate and adaptive immune function, resulting in autoantibodies production. The most …
The Role of Interferon Gene Signature in Systemic Lupus …
2024年1月9日 · Type 1 interferons (IFNs) play a central role in the development and disease course of systemic lupus erythematosus (SLE). In a new study, researchers explored SLE …
IFN- γ Mediates the Development of Systemic Lupus Erythematosus
2020年10月17日 · Our findings suggest that interferon-related gene expression and pathways are common features for SLE pathogenesis, and IFN-<i>γ</i> and IFN-<i>γ</i>-inducible GBP1 …
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