2022年5月4日 · Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte...

2021年10月1日 · Sphingosine-1-phosphate (S1P) is a bioactive lipid derived from sphingolipid metabolism and fulfills its biological function by coupling with its five receptors. In SLE, S1P functions as an important mediator by regulating both inflammatory and immune responses. On one hand, S1P plays a detrimental role by interacting with different immune cells.

2024年11月9日 · The bioactive lipid sphingosine-1-phosphate (S1P), acting via S1P receptor 1 (S1P 1), is a key regulator of endothelial cell (EC) barrier function. We hypothesized that augmenting EC integrity via S1P 1 signaling would attenuate inflammatory injury mediated by ICs.

Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The S1P-S1PR signalling axis is a key component of the inflammatory response in autoimmune rheumatic diseases.

2024年11月22日 · Sphingosine-1-phosphate (S1P) is involved in lymphocyte egress from peripheral lymphoid organs into the circulation. In phase 2a clinical trial, the potent, selective S1P 1 receptor modulator cenerimod reduced circulating antibody-secreting cells and interferon (IFN)-associated biomarkers.

Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The S1P–S1PR signalling axis is a key component of the inflammatory response in autoimmune rheumatic diseases.

狼疮性肾炎（LN）是系统性红斑狼疮（SLE）的常见并发症，也是 患者死亡的主要原因。 先前的研究表明，SLE 患者和小鼠狼疮模型的血浆样本中 S1P 水平升高。 FTY720 ，靶向S1P受体，在改善狼疮小鼠模型的肾炎症状方面表现出治疗作用。 然而，很少有研究讨论 S1P/S1PR 与 LN 发病机制的潜在相关性。 巨噬细胞已被证明是肾脏炎症的重要致病因子，而促炎性 M1 型巨噬细胞会在 LN 期间促进肾脏损伤和炎症。 重要的是，巨噬细胞表达各种 S1P 受体，并且它们在 LN 环境 …

Sphingosine-1-phosphate (S1P) is involved in lymphocyte egress from peripheral lymphoid organs into the circulation. In phase 2a clinical trial, the potent, selective S1P 1 receptor modulator cenerimod reduced circulating antibody-secreting cells …

Sphingosine-1-phosphate (S1P) is a central bioactive lipid of sphingolipid metabolism, which serves a pivotal role in regulating numerous physiological and pathological processes. As a well-recognized regulator of lymphocyte trafficking, S1P has been shown to be closely associated with autoimmune diseases, including SLE.

2024年11月22日 · Sphingosine- 1- phosphate (S1P) is involved in lymphocyte egress from peripheral lymphoid organs into the circulation. In phase 2a clinical trial, the potent, selective S1P. 1 receptor modulator cenerimod reduced circulating antibody- secreting cells and interferon (IFN)- associated biomarkers.