Sphingomyelin synthase SMS2 displays dual activity as ceramide ...
2009年11月1日 · We now demonstrate that SMS family members display striking differences in substrate specificity, with SMS1 and SMSr being monofunctional enzymes with SM and CPE …
Protein probes to visualize sphingomyelin and ceramide ...
2018年11月1日 · Sphingomyelin (SM) is a major sphingolipid in mammalian cells whereas its analog, ceramide phosphoethanolamine (CPE) is found in trace amounts in mammalian cells …
Switching head group selectivity in mammalian ... - ScienceDirect
2017年5月1日 · In SMS-catalyzed SM/CPE production, transfer of the PC/PE head group onto ceramide is thought to proceed via formation of a choline/ethanolamine phospho-His …
Cryo-EM structure of human sphingomyelin synthase and its …
2024年2月22日 · Here we determined the cryo-electron microscopic structures of human SMSr in complexes with ceramide, diacylglycerol/phosphoethanolamine and …
Switching head group selectivity in mammalian sphingolipid
Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma membrane. …
可视化鞘磷脂和神经酰胺磷酸乙醇胺的蛋白探针,Chemistry and …
鞘磷脂（SM）是哺乳动物细胞中的主要鞘脂，而其类似物神经酰胺磷酸乙醇胺（CPE）在哺乳动物细胞中存在痕量，而在无脊椎动物如昆虫果蝇（Drosophila melanogaster）等无脊椎动物中 …
Protein probes to visualize sphingomyelin and ceramide ...
Sphingomyelin (SM) is a major sphingolipid in mammalian cells whereas its analog, ceramide phosphoethanolamine (CPE) is found in trace amounts in mammalian cells and in larger …
All members in the sphingomyelin synthase gene family have …
Sphingomyelin synthase-related protein (SMSr) synthesizes the sphingomyelin analog ceramide phosphoethanolamine (CPE) in cells. Previous cell studies indicated that SMSr is involved in …
Sphingomyelin synthase family and phospholipase Cs - PMC
The sphingomyelin synthase (SMS) gene family has three members: SMS1 and SMS2 have SM synthase activity, while SMS-related protein (SMSr) has no SM synthase activity but has …
Ceramide Phosphoethanolamine Biosynthesis in - Journal of …
Drosophila lacks SM and instead synthesizes the SM analogue ceramide phosphoethanolamine (CPE) as the principal membrane sphingolipid. The corresponding CPE synthase shares …